AGTR1 Antibody - N-terminal region (ARP42198_P050)

Data Sheet
 
Product Number ARP42198_P050
Product Page www.avivasysbio.com/agtr1-antibody-n-terminal-region-arp42198-p050.html
Name AGTR1 Antibody - N-terminal region (ARP42198_P050)
Protein Size (# AA) 359 amino acids
Molecular Weight 41kDa
NCBI Gene Id 185
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Angiotensin II receptor, type 1
Alias Symbols AT1, AG2S, AT1B, AT1R, AT1AR, AT1BR, AT2R1, HAT1R, AGTR1B
Peptide Sequence Synthetic peptide located within the following region: ILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVI
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Kurland,L., (2008) Am. J. Hypertens. 21 (7), 836-839
Description of Target Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. AGTR1 is the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. AGTR1 may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans.Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants.
Protein Interactions PDE6H; GNB2L1; HTR2B; ARRB2; ARRB1; JAK2; TRAF3; MAPK1; AGTRAP; DNAJC14; THOP1; GRK5; GPRASP1; HRAS; RAB5A; PLCG1; RAF1; NOS3; EGFR; BDKRB2; ADRBK2; ADRBK1; AGT; ZBTB16;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-AGTR1 (ARP42198_P050) antibody
Blocking Peptide For anti-AGTR1 (ARP42198_P050) antibody is Catalog # AAP42198 (Previous Catalog # AAPP12578)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human AGTR1
Uniprot ID P30556
Protein Name Type-1 angiotensin II receptor
Protein Accession # NP_004826
Purification Affinity Purified
Nucleotide Accession # NM_004835
Tested Species Reactivity Human, Mouse
Gene Symbol AGTR1
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%
Image 1
Mouse Brain Membranes
AGTR1 antibody - N-terminal region (ARP42198_P050) validated by WB using Mouse Brain Membranes at 1:4000.
Image 2
Human heart
WB Suggested Anti-AGTR1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human heart
 

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