AGTR1 Antibody - N-terminal region (ARP42198_P050)

• Product Number: ARP42198_P050
• Name: AGTR1 Antibody - N-terminal region (ARP42198_P050)
• Protein Size (# AA): 359 amino acids
• Molecular Weight: 41kDa
• NCBI Gene Id: 185
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Angiotensin II receptor, type 1
• Alias Symbols: AT1, AG2S, AT1B, AT1R, AT1AR, AT1BR, AT2R1, HAT1R, AGTR1B
• Peptide Sequence: Synthetic peptide located within the following region: ILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVI
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Kurland,L., (2008) Am. J. Hypertens. 21 (7), 836-839
• Description of Target: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. AGTR1 is the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. AGTR1 may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans.Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants.
• Protein Interactions: PDE6H; GNB2L1; HTR2B; ARRB2; ARRB1; JAK2; TRAF3; MAPK1; AGTRAP; DNAJC14; THOP1; GRK5; GPRASP1; HRAS; RAB5A; PLCG1; RAF1; NOS3; EGFR; BDKRB2; ADRBK2; ADRBK1; AGT; ZBTB16;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-AGTR1 (ARP42198_P050) antibody is Catalog # AAP42198 (Previous Catalog # AAPP12578)
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human AGTR1
• Uniprot ID: P30556
• Protein Name: Type-1 angiotensin II receptor
• Protein Accession #: NP_004826
• Purification: Affinity Purified
• Nucleotide Accession #: NM_004835
• Tested Species Reactivity: Human, Mouse
• Gene Symbol: AGTR1
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%
• Image 1: Mouse Brain Membranes
  
  AGTR1 antibody - N-terminal region (ARP42198_P050) validated by WB using Mouse Brain Membranes at 1:4000.
• Image 2: Human heart
  
  WB Suggested Anti-AGTR1 Antibody Titration: 0.2-1 ug/ml
  ELISA Titer: 1:62500
  Positive Control: Human heart