| Product Number |
ARP42148_P050 |
| Product Page |
www.avivasysbio.com/socs1-antibody-middle-region-arp42148-p050.html |
| Name |
SOCS1 Antibody - middle region (ARP42148_P050) |
| Protein Size (# AA) |
211 amino acids |
| Molecular Weight |
23kDa |
| NCBI Gene Id |
8651 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Suppressor of cytokine signaling 1 |
| Alias Symbols |
JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, TIP-3, SOCS-1 |
| Peptide Sequence |
Synthetic peptide located within the following region: RQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVA |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. |
| Protein Interactions |
CSF2RB; TCEB1; ERBB2; ABL1; CYTIP; gag; TP53; JAK2; ATR; ATM; JAK1; INSR; FGFR3; LCK; RASA1; PDCD1; IRS1; ETV6; DAB1; TIRAP; VHL; VAV1; TUBG1; RELA; MAP3K5; CLEC7A; PTPN11; TYK2; IRF3; IFNAR1; TCEB2; ALK; COMMD1; TRIM8; PIK3R2; GHR; IRS2; TEC; NCK1; VAV2; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-SOCS1 (ARP42148_P050) antibody |
| Blocking Peptide |
For anti-SOCS1 (ARP42148_P050) antibody is Catalog # AAP42148 (Previous Catalog # AAPS11809) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human SOCS1 |
| Uniprot ID |
O15524 |
| Protein Name |
Suppressor of cytokine signaling 1 |
| Protein Accession # |
NP_003736 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_003745 |
| Tested Species Reactivity |
Human, Rat |
| Gene Symbol |
SOCS1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% |
| Image 1 | Rat liver
 | Rat liver |
|
| Image 2 | Human ACHN
 | WB Suggested Anti-SOCS1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: ACHN cell lysate |
|
