| Product Number |
ARP42042_P050 |
| Product Page |
www.avivasysbio.com/mmp3-antibody-middle-region-arp42042-p050.html |
| Name |
MMP3 Antibody - middle region (ARP42042_P050) |
| Protein Size (# AA) |
477 amino acids |
| Molecular Weight |
43kDa |
| NCBI Gene Id |
4314 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Matrix metallopeptidase 3 (stromelysin 1, progelatinase) |
| Description |
|
| Alias Symbols |
SL-1, STMY, STR1, CHDS6, MMP-3, STMY1 |
| Peptide Sequence |
Synthetic peptide located within the following region: AEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLN |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Stickel,F., (2008) Alcohol. Clin. Exp. Res. 32 (6), 959-965 |
| Description of Target |
MMP3 can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. MMP3 activates procollagenase.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
MEOX2; SPOCK3; SPOCK1; TNFSF11; CCL8; CCL13; BCAN; TIMP1; TIMP3; MMP3; SERPINE1; PLG; SPP1; CCL7; CCL2; ACAN; IGFBP3; DCN; HAPLN1; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-MMP3 (ARP42042_P050) antibody |
| Blocking Peptide |
For anti-MMP3 (ARP42042_P050) antibody is Catalog # AAP42042 (Previous Catalog # AAPP24523) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human MMP3 |
| Uniprot ID |
P08254 |
| Protein Name |
Stromelysin-1 |
| Publications |
Clusterin secretion is attenuated by the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in models of cartilage degradation. J Orthop Res. (2020) 32725904 |
| Protein Accession # |
NP_002413 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_002422 |
| Tested Species Reactivity |
Human, Horse |
| Gene Symbol |
MMP3 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 93%; Rat: 93% |
| Image 1 | Human Jurkat
 | WB Suggested Anti-MMP3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Jurkat cell lysate |
|
| Image 2 | Human colorectal cancer
 | Application: IHC
Species+tissue/cell type: Control-Human small intestine, Sample-human colorectal cancer
Primary antibody dilution: 1:100
Secondary antibody: Biotinylated pig anti-rabbit+streptavidin-HRP |
|
| Image 3 | Equine Cartilage Explants
 | Sample Type: Equine Cartilage Explants
Primary Dilution: 1:1000
Secondary: Abcam ab97200 (Dilution: 1:20,000) |
|
| Image 4 | Equine Cartilage Explants
 | MMP3 antibody - middle region (ARP42042_P050) validated by WB using Equine Cartilage Explants at 1:1000. |
|
