TSHR Antibody - C-terminal region (ARP41871_P050)

Data Sheet
 
Product Number ARP41871_P050
Product Page www.avivasysbio.com/tshr-antibody-c-terminal-region-arp41871-p050.html
Name TSHR Antibody - C-terminal region (ARP41871_P050)
Protein Size (# AA) 764 amino acids
Molecular Weight 87 kDa
NCBI Gene Id 7253
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Thyroid stimulating hormone receptor
Alias Symbols LGR3, CHNG1, hTSHR-I
Peptide Sequence Synthetic peptide located within the following region: KLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLLPLGRKSLSFETQKAPRSS
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Claus,M., (2005) Endocrinology 146 (12), 5197-5203
Description of Target TSHR is receptor for thyrothropin. It plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. It also acts as a receptor for thyrostimulin (GPA2+GPB5).
Protein Interactions ADRB2; SCRIB; UBC; TSHB; RABAC1; GNA13; GNA12; FLNB; TSHR; GNAQ; PIK3R1; LHCGR; JAK2; JAK1; GNAI3; GNAI2; GNAS; GNA11; GNAO1; GNAI1; HSPA5; FN1; CANX; CALR; STAT3; CALCR;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Enhanced Validation
Relative Expression (Western Blot) Avivasheild
Datasheets/Manuals Printable datasheet for anti-TSHR (ARP41871_P050) antibody
Blocking Peptide For anti-TSHR (ARP41871_P050) antibody is Catalog # AAP41871 (Previous Catalog # AAPP24408)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human TSHR
Uniprot ID Q96GT6
Protein Name Thyrotropin receptor
Publications

Pessina, P., Castillo, V., Sartore, I., Borrego, J. & Meikle, A. Semiquantitative immunohistochemical marker staining and localization in canine thyroid carcinoma and normal thyroid gland. Vet. Comp. Oncol. (2014). doi:10.1111/vco.12111 25082554

Sample Type Confirmation

There is BioGPS gene expression data showing that TSHR is expressed in Jurkat

Protein Accession # NP_001018046
Purification Affinity Purified
Nucleotide Accession # NM_001018036
Tested Species Reactivity Human
Gene Symbol TSHR
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 83%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 86%; Rabbit: 86%; Rat: 93%; Sheep: 79%
Image 1
Human Jurkat
WB Suggested Anti-TSHR Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysateThere is BioGPS gene expression data showing that TSHR is expressed in Jurkat. The peptide sequence is present in a 28 kDa isoform.
Image 2
Human HepG2 Whole Cell
Host: Rabbit
Target Name: TSHR
Sample Tissue: Human HepG2 Whole Cell
Antibody Dilution: 1ug/ml
 

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