Product Number |
ARP41759_P050 |
Product Page |
www.avivasysbio.com/fga-antibody-middle-region-arp41759-p050.html |
Name |
FGA Antibody - middle region (ARP41759_P050) |
Protein Size (# AA) |
644 amino acids |
Molecular Weight |
66kDa |
NCBI Gene Id |
2243 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Fibrinogen alpha chain |
Alias Symbols |
Fib2 |
Peptide Sequence |
Synthetic peptide located within the following region: SSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAK |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Jood,K., (2008) J. Thromb. Haemost. 6 (6), 897-904 |
Description of Target |
FGA is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in its gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. |
Protein Interactions |
ASB7; ASB6; FN1; APOA1; ALB; UBC; SUMO2; MIS12; KHDRBS2; ITGA2B; SERPINA5; CDH5; SERPINF2; THBS1; F2; ITGB3; PLAT; HRG; PRRC2A; FGG; FGB; FGA; F13A1; NID1; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-FGA (ARP41759_P050) antibody |
Blocking Peptide |
For anti-FGA (ARP41759_P050) antibody is Catalog # AAP41759 (Previous Catalog # AAPP10807) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human FGA |
Uniprot ID |
Q4QQH7 |
Protein Name |
Fibrinogen alpha chain |
Publications |
Matsumoto, M. et al. An efficient system for secretory production of fibrinogen using a hepatocellular carcinoma cell line. Hepatol. Res. (2014). doi:10.1111/hepr.12353 24802089
Prieto-GarcÃa, A. et al. Mast cell restricted mouse and human tryptase·heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen. J. Biol. Chem. 287, 7834-44 (2012). 22235124 |
Protein Accession # |
NP_068657 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_021871 |
Tested Species Reactivity |
Human |
Gene Symbol |
FGA |
Predicted Species Reactivity |
Human |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Human: 100% |
Image 1 | Human NCI-H226
| Host: Rabbit Target Name: FGA Sample Tissue: Human NCI-H226 Antibody Dilution: 1.0ug/ml |
|
Image 2 | Human liver, Human stomach
| Host: Rabbit Target: FGA Positive control (+): Human liver (LI) Negative control (-): Human stomach (ST) Antibody concentration: 1ug/ml |
|
Image 3 | Human 786-0 Whole Cell
| Host: Rabbit Target Name: FGA Sample Tissue: Human 786-0 Whole Cell Antibody Dilution: 1ug/ml |
|