FGA Antibody - middle region (ARP41759_P050)

Data Sheet
 
Product Number ARP41759_P050
Product Page www.avivasysbio.com/fga-antibody-middle-region-arp41759-p050.html
Name FGA Antibody - middle region (ARP41759_P050)
Protein Size (# AA) 644 amino acids
Molecular Weight 66kDa
NCBI Gene Id 2243
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Fibrinogen alpha chain
Alias Symbols Fib2
Peptide Sequence Synthetic peptide located within the following region: SSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAK
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Jood,K., (2008) J. Thromb. Haemost. 6 (6), 897-904
Description of Target FGA is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in its gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus.
Protein Interactions ASB7; ASB6; FN1; APOA1; ALB; UBC; SUMO2; MIS12; KHDRBS2; ITGA2B; SERPINA5; CDH5; SERPINF2; THBS1; F2; ITGB3; PLAT; HRG; PRRC2A; FGG; FGB; FGA; F13A1; NID1;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-FGA (ARP41759_P050) antibody
Blocking Peptide For anti-FGA (ARP41759_P050) antibody is Catalog # AAP41759 (Previous Catalog # AAPP10807)
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human FGA
Uniprot ID Q4QQH7
Protein Name Fibrinogen alpha chain
Publications

Matsumoto, M. et al. An efficient system for secretory production of fibrinogen using a hepatocellular carcinoma cell line. Hepatol. Res. (2014). doi:10.1111/hepr.12353 24802089

Prieto-García, A. et al. Mast cell restricted mouse and human tryptase·heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen. J. Biol. Chem. 287, 7834-44 (2012). 22235124

Protein Accession # NP_068657
Purification Affinity Purified
Nucleotide Accession # NM_021871
Tested Species Reactivity Human
Gene Symbol FGA
Predicted Species Reactivity Human
Application WB
Predicted Homology Based on Immunogen Sequence Human: 100%
Image 1
Human NCI-H226
Host: Rabbit
Target Name: FGA
Sample Tissue: Human NCI-H226
Antibody Dilution: 1.0ug/ml
Image 2
Human liver, Human stomach
Host: Rabbit
Target: FGA
Positive control (+): Human liver (LI)
Negative control (-): Human stomach (ST)
Antibody concentration: 1ug/ml
Image 3
Human 786-0 Whole Cell
Host: Rabbit
Target Name: FGA
Sample Tissue: Human 786-0 Whole Cell
Antibody Dilution: 1ug/ml
 

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