| Product Number |
ARP41456_P050 |
| Product Page |
www.avivasysbio.com/muc1-antibody-middle-region-arp41456-p050.html |
| Name |
MUC1 Antibody - middle region (ARP41456_P050) |
| Protein Size (# AA) |
158 amino acids |
| Molecular Weight |
14kDa |
| NCBI Gene Id |
4582 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Mucin 1, cell surface associated |
| Alias Symbols |
EMA, MCD, PEM, PUM, KL-6, MAM6, MCKD, PEMT, CD227, H23AG, MCKD1, MUC-1, ADMCKD, ADTKD2, ADMCKD1, CA 15-3, MUC-1/X, MUC1/ZD, MUC-1/SEC |
| Peptide Sequence |
Synthetic peptide located within the following region: GCAGHCLSHCLGCLSVPPKELRAAGHLSSPGYLPSYERVPHLPHPWALCA |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Creaney,J., (2008) Br. J. Cancer 98 (9), 1562-1569 |
| Description of Target |
MUC1 is a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined. |
| Protein Interactions |
UBC; PPARG; IPO5; NUP62; EGFR; ABL1; SRC; JUN; TP53; TBP; IKBKG; TNFRSF1A; IKBKB; GRB2; ESR1; GALNT15; GALNT12; GALNT10; OSGEP; GSK3B; GALNT2; GALNT1; CTNND1; SIGLEC1; ERBB4; ERBB3; SOS1; PRKCD; ZAP70; APC; JUP; LYN; ERBB2; LCK; CTNNB1; GALNT4; BAX; CDKN1 |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-MUC1 (ARP41456_P050) antibody |
| Blocking Peptide |
For anti-MUC1 (ARP41456_P050) antibody is Catalog # AAP41456 (Previous Catalog # AAPP24193) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human MUC1 |
| Uniprot ID |
Q7Z538 |
| Protein Name |
Mucin short variant PC2 EMBL AAP97027.1 |
| Protein Accession # |
NP_001037858 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_001044393 |
| Tested Species Reactivity |
Human, Mouse |
| Gene Symbol |
MUC1 |
| Predicted Species Reactivity |
Human, Pig |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Human: 100%; Pig: 86% |
| Image 1 | Human Jurkat
 | WB Suggested Anti-MUC1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysate |
| | Image 2 | Mouse
 | NMuFG s |
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