ASS Antibody - N-terminal region (ARP41366_T100)

Data Sheet
 
Product Number ARP41366_T100
Product Page www.avivasysbio.com/ass-antibody-n-terminal-region-arp41366-t100.html
Name ASS Antibody - N-terminal region (ARP41366_T100)
Protein Size (# AA) 412 amino acids
Molecular Weight 45kDa
NCBI Gene Id 445
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name Argininosuccinate synthase 1
Description
Alias Symbols ASS, CTLN1
Peptide Sequence Synthetic peptide located within the following region: YSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVF
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Hao,G., (2004) J. Biol. Chem. 279 (35), 36192-36200
Description of Target ASS catalyzes the penultimate step of the arginine biosynthetic pathway.The protein encoded by this gene catalyzes the penultimate step of the arginine biosynthetic pathway. There are approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase. Mutations in the chromosome 9 copy of ASS cause citrullinemia. Two transcript variants encoding the same protein have been found for this gene.
Protein Interactions ASS1; UBC; ASB18; ASB9; NHLRC2; ATG3; CNDP2; NANS; TNFAIP8; NAMPT; DPP3; RPL23; CTSA; PEPD; MVD; HSPA9; GSS; GBP2; EIF4E; DLD; CAPN1; FBXO6; LATS1; MT2A; MLH1; JAK2; PTPN1; GIT2; SPR; APP; USP4; TERF2; TERF1; SUMO2; AI837181; MYC; ASCC2; AKTIP; ARAF; ELN;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-ASS1 (ARP41366_T100) antibody
Blocking Peptide For anti-ASS1 (ARP41366_T100) antibody is Catalog # AAP41366 (Previous Catalog # AAPP24105)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human ASS
Uniprot ID P00966
Protein Name Argininosuccinate synthase
Publications

Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts. PLoS One. 9, e100077 (2014). 24945279

Argininosuccinate neurotoxicity and prevention by creatine in argininosuccinate lyase deficiency: An in vitro study in rat three-dimensional organotypic brain cell cultures. J Inherit Metab Dis. 42, 1077-1087 (2019) 30907007

Protein Accession # NP_446464
Purification Protein A purified
Nucleotide Accession # NM_054012
Tested Species Reactivity Human
Gene Symbol ASS1
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Yeast, Zebrafish
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Yeast: 86%; Zebrafish: 79%
Image 1
Human Kidney
Rabbit Anti-ASS Antibody
Catalog Number: ARP41366
Paraffin Embedded Tissue: Human Kidney
Cellular Data: Epithelial cells of renal tubule
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X
Image 2
Human HepG2
WB Suggested Anti-ASS Antibody Titration: 2.5ug/ml
Positive Control: HepG2 cell lysate
 

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