| Product Number |
ARP41351_P050 |
| Product Page |
www.avivasysbio.com/msh2-antibody-n-terminal-region-arp41351-p050.html |
| Name |
MSH2 Antibody - N-terminal region (ARP41351_P050) |
| Protein Size (# AA) |
934 amino acids |
| Molecular Weight |
105kDa |
| NCBI Gene Id |
4436 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
MutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) |
| Alias Symbols |
FCC1, COCA1, HNPCC, LCFS2, hMSH2, HNPCC1, MMRCS2 |
| Peptide Sequence |
Synthetic peptide located within the following region: GNKASKENDWYLAYKASPGNLSQFEDILFGNNDMSASIGVVGVKMSAVDG |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Magnusson,S., (er) Fam. Cancer (2008) In press |
| Description of Target |
MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
ESR1; BRCA1; SUMO2; RPA3; RPA2; RPA1; REV1; POLK; DPYSL3; ATP6V1B2; CUL2; XRCC5; SUPT5H; STAT3; ST13; PDE3A; NRD1; JUP; XRCC6; SEC23A; HDAC6; PCNA; MSH3; MSH6; ERCC4; ERCC1; gag-pol; UBC; SUPT16H; SEPT9; SRSF10; SRSF11; SART1; SMARCA5; TOP2B; SRSF7; SRSF5 |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-MSH2 (ARP41351_P050) antibody |
| Blocking Peptide |
For anti-MSH2 (ARP41351_P050) antibody is Catalog # AAP41351 (Previous Catalog # AAPS01510) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human MSH2 |
| Uniprot ID |
P43246 |
| Protein Name |
DNA mismatch repair protein Msh2 |
| Protein Accession # |
NP_000242 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_000251 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
MSH2 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%; Zebrafish: 79% |
| Image 1 | Human kidney
 | Sample Type: Human KidneyPrimary
Dilution: 1ug/mL |
|
| Image 2 | Human HepG2
 | WB Suggested Anti-MSH2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate |
|
