HNRPAB Antibody - C-terminal region (ARP41036_T100)

Data Sheet
 
Product Number ARP41036_T100
Product Page www.avivasysbio.com/hnrpab-antibody-c-terminal-region-arp41036-t100.html
Name HNRPAB Antibody - C-terminal region (ARP41036_T100)
Protein Size (# AA) 332 amino acids
Molecular Weight 37kDa
NCBI Gene Id 3182
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name Heterogeneous nuclear ribonucleoprotein A/B
Alias Symbols ABBP1, HNRPAB
Peptide Sequence Synthetic peptide located within the following region: QQGYGPGYGGYDYSPYGYYGYGPGYDYSQGSTNYGKSQRRGGHQNNYKPY
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Gao,C., (2004) J. Biol. Chem. 279 (12), 11236-11243
Description of Target This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs.This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Protein Interactions UBC; SUMO2; IVNS1ABP; STAU1; DROSHA; MDM2; LIN28A; RPA3; RPA2; RPA1; ERG; RNF2; EZH2; EED; rev; YBX1; LDHB; TARDBP; HMGA1; USP19; PAN2; PTBP2; TP63; UBL4A; WHSC1; PTBP1; ITGA4; IL7R; IFIT3; IFIT2; FN1; SMURF1; ESR1; HNRNPA2B1; ATP6AP1; MRPS25; MRPS7; MRPS
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-HNRNPAB (ARP41036_T100) antibody
Blocking Peptide For anti-HNRNPAB (ARP41036_T100) antibody is Catalog # AAP41036 (Previous Catalog # AAPS02301)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human HNRPAB
Uniprot ID Q99729-2
Protein Name Heterogeneous nuclear ribonucleoprotein A/B
Publications

Bubenik, J. L., Ladd, A. N., Gerber, C. A., Budiman, M. E. & Driscoll, D. M. Known turnover and translation regulatory RNA-binding proteins interact with the 3’ UTR of SECIS-binding protein 2. RNA Biol. 6, 73-83 (2009). 19106619

Taga, Y., Miyoshi, M., Okajima, T., Matsuda, T. & Nadano, D. Identification of heterogeneous nuclear ribonucleoprotein A/B as a cytoplasmic mRNA-binding protein in early involution of the mouse mammary gland. Cell Biochem. Funct. 28, 321-8 (2010). 20517897

Sample Type Confirmation

HNRNPAB is supported by BioGPS gene expression data to be expressed in Daudi

Protein Accession # NP_112556
Purification Protein A purified
Nucleotide Accession # NM_031266
Tested Species Reactivity Human
Gene Symbol HNRNPAB
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 93%; Zebrafish: 93%
Image 1
Human Daudi
WB Suggested Anti-HNRPAB Antibody Titration: 1.25ug/ml
Positive Control: Daudi cell lysateHNRNPAB is supported by BioGPS gene expression data to be expressed in Daudi
Image 2
Human Heart
Rabbit Anti-HNRNPAB Antibody
Catalog Number: ARP41036
Paraffin Embedded Tissue: Human cardiac cell
Cellular Data: Epithelial cells of renal tubule
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X
Image 3
Human Lung
Rabbit Anti-HNRPAB Antibody
Catalog Number: ARP41036
Paraffin Embedded Tissue: Human Lung
Cellular Data: Alveolar cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X
Image 4
Human Heart
Rabbit Anti-HNRPAB Antibody
Catalog Number: ARP41036
Paraffin Embedded Tissue: Human Heart
Cellular Data: Myocardial cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X
 

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