Product Number |
ARP41036_T100 |
Product Page |
www.avivasysbio.com/hnrpab-antibody-c-terminal-region-arp41036-t100.html |
Name |
HNRPAB Antibody - C-terminal region (ARP41036_T100) |
Protein Size (# AA) |
332 amino acids |
Molecular Weight |
37kDa |
NCBI Gene Id |
3182 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
Heterogeneous nuclear ribonucleoprotein A/B |
Alias Symbols |
ABBP1, HNRPAB |
Peptide Sequence |
Synthetic peptide located within the following region: QQGYGPGYGGYDYSPYGYYGYGPGYDYSQGSTNYGKSQRRGGHQNNYKPY |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Gao,C., (2004) J. Biol. Chem. 279 (12), 11236-11243 |
Description of Target |
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs.This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
Protein Interactions |
UBC; SUMO2; IVNS1ABP; STAU1; DROSHA; MDM2; LIN28A; RPA3; RPA2; RPA1; ERG; RNF2; EZH2; EED; rev; YBX1; LDHB; TARDBP; HMGA1; USP19; PAN2; PTBP2; TP63; UBL4A; WHSC1; PTBP1; ITGA4; IL7R; IFIT3; IFIT2; FN1; SMURF1; ESR1; HNRNPA2B1; ATP6AP1; MRPS25; MRPS7; MRPS |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-HNRNPAB (ARP41036_T100) antibody |
Blocking Peptide |
For anti-HNRNPAB (ARP41036_T100) antibody is Catalog # AAP41036 (Previous Catalog # AAPS02301) |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human HNRPAB |
Uniprot ID |
Q99729-2 |
Protein Name |
Heterogeneous nuclear ribonucleoprotein A/B |
Publications |
Bubenik, J. L., Ladd, A. N., Gerber, C. A., Budiman, M. E. & Driscoll, D. M. Known turnover and translation regulatory RNA-binding proteins interact with the 3â UTR of SECIS-binding protein 2. RNA Biol. 6, 73-83 (2009). 19106619
Taga, Y., Miyoshi, M., Okajima, T., Matsuda, T. & Nadano, D. Identification of heterogeneous nuclear ribonucleoprotein A/B as a cytoplasmic mRNA-binding protein in early involution of the mouse mammary gland. Cell Biochem. Funct. 28, 321-8 (2010). 20517897 |
Sample Type Confirmation |
HNRNPAB is supported by BioGPS gene expression data to be expressed in Daudi |
Protein Accession # |
NP_112556 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_031266 |
Tested Species Reactivity |
Human |
Gene Symbol |
HNRNPAB |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 93%; Zebrafish: 93% |
Image 1 | Human Daudi
| WB Suggested Anti-HNRPAB Antibody Titration: 1.25ug/ml Positive Control: Daudi cell lysateHNRNPAB is supported by BioGPS gene expression data to be expressed in Daudi |
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Image 2 | Human Heart
| Rabbit Anti-HNRNPAB Antibody Catalog Number: ARP41036 Paraffin Embedded Tissue: Human cardiac cell Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X |
|
Image 3 | Human Lung
| Rabbit Anti-HNRPAB Antibody Catalog Number: ARP41036 Paraffin Embedded Tissue: Human Lung Cellular Data: Alveolar cells Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X |
|
Image 4 | Human Heart
| Rabbit Anti-HNRPAB Antibody Catalog Number: ARP41036 Paraffin Embedded Tissue: Human Heart Cellular Data: Myocardial cells Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X |
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