Product Number |
ARP40984_P050-FITC |
Product Page |
www.avivasysbio.com/dgcr8-antibody-n-terminal-region-fitc-arp40984-p050-fitc.html |
Name |
DGCR8 Antibody - N-terminal region : FITC (ARP40984_P050-FITC) |
Protein Size (# AA) |
773 amino acids |
Molecular Weight |
85kDa |
Subunit |
DGCR8 |
Conjugation |
FITC: Fluorescein Isothiocyanate |
NCBI Gene Id |
54487 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
DiGeorge syndrome critical region gene 8 |
Alias Symbols |
Gy1, pasha, DGCRK6, C22orf12 |
Peptide Sequence |
Synthetic peptide located within the following region: DKKDEENELDQEKRVEYAVLDELEDFTDNLELDEEGAGGFTAKAIVQRDR |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer. |
Reference |
Shiohama,A., (2007) Exp. Cell Res. 313 (20), 4196-4207 |
Description of Target |
DGCR8 contains 2 DRBM (double-stranded RNA-binding) domains and 1 WW domain. It may play a part in the etiology of the velocardiofacial/DiGeorge syndrome (VCFS/DGS), a developmental disorder characterized by structural and functional palate anomalies, conotruncal cardiac malformations, immunodeficiency, hypocalcemia, and typical facial anomalies. |
Protein Interactions |
MEOX2; PYCRL; DROSHA; RAE1; MAPK1; PRMT1; ERH; CDKN2A; BMI1; SRPK2; SRPK1; CDT1; NAT10; PLEK2; RPRD2; MAPRE2; PRPF4; FLII; APP; CUL3; DDX17; HNRNPR; NCL; ILF3; HSPA8; HSPA5; HNRNPU; HNRNPH1; FUS; DHX9; DDX5; |
Reconstitution and Storage |
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
Datasheets/Manuals |
Printable datasheet for anti-DGCR8 (ARP40984_P050-FITC) antibody |
Additional Information |
IHC Information: Paraffin embedded liver tissue, tested with an antibody dilution of 5 ug/ml. |
Blocking Peptide |
For anti-DGCR8 (ARP40984_P050-FITC) antibody is Catalog # AAP40984 (Previous Catalog # AAPS02002) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human DGCR8 |
Uniprot ID |
Q8WYQ5 |
Protein Name |
Microprocessor complex subunit DGCR8 |
Publications |
Kye, M. J. et al. NMDA mediated contextual conditioning changes miRNA expression. PLoS One 6, e24682 (2011). WB, IHC, Rat, Dog, Pig, Guinea pig, Human, Mouse, Rabbit, Horse, Bovine, Zebrafish 21931811 Van Duyne, R. et al. Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery. PLoS One 7, e40662 (2012). WB, IHC, Rat, Dog, Pig, Guinea pig, Human, Mouse, Rabbit, Horse, Bovine, Zebrafish 22808228 |
Protein Accession # |
NP_073557 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_022720 |
Gene Symbol |
DGCR8 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 85%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 77% |
Image 1 | |