DGCR8 Antibody - N-terminal region : FITC (ARP40984_P050-FITC)

Data Sheet
 
Product Number ARP40984_P050-FITC
Product Page www.avivasysbio.com/dgcr8-antibody-n-terminal-region-fitc-arp40984-p050-fitc.html
Name DGCR8 Antibody - N-terminal region : FITC (ARP40984_P050-FITC)
Protein Size (# AA) 773 amino acids
Molecular Weight 85kDa
Subunit DGCR8
Conjugation FITC: Fluorescein Isothiocyanate
NCBI Gene Id 54487
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name DiGeorge syndrome critical region gene 8
Alias Symbols Gy1, pasha, DGCRK6, C22orf12
Peptide Sequence Synthetic peptide located within the following region: DKKDEENELDQEKRVEYAVLDELEDFTDNLELDEEGAGGFTAKAIVQRDR
Product Format Liquid. Purified antibody supplied in 1x PBS buffer.
Reference Shiohama,A., (2007) Exp. Cell Res. 313 (20), 4196-4207
Description of Target DGCR8 contains 2 DRBM (double-stranded RNA-binding) domains and 1 WW domain. It may play a part in the etiology of the velocardiofacial/DiGeorge syndrome (VCFS/DGS), a developmental disorder characterized by structural and functional palate anomalies, conotruncal cardiac malformations, immunodeficiency, hypocalcemia, and typical facial anomalies.
Protein Interactions MEOX2; PYCRL; DROSHA; RAE1; MAPK1; PRMT1; ERH; CDKN2A; BMI1; SRPK2; SRPK1; CDT1; NAT10; PLEK2; RPRD2; MAPRE2; PRPF4; FLII; APP; CUL3; DDX17; HNRNPR; NCL; ILF3; HSPA8; HSPA5; HNRNPU; HNRNPH1; FUS; DHX9; DDX5;
Reconstitution and Storage All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Datasheets/Manuals Printable datasheet for anti-DGCR8 (ARP40984_P050-FITC) antibody
Additional Information IHC Information: Paraffin embedded liver tissue, tested with an antibody dilution of 5 ug/ml.
Blocking Peptide For anti-DGCR8 (ARP40984_P050-FITC) antibody is Catalog # AAP40984 (Previous Catalog # AAPS02002)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human DGCR8
Uniprot ID Q8WYQ5
Protein Name Microprocessor complex subunit DGCR8
Publications

Kye, M. J. et al. NMDA mediated contextual conditioning changes miRNA expression. PLoS One 6, e24682 (2011). WB, IHC, Rat, Dog, Pig, Guinea pig, Human, Mouse, Rabbit, Horse, Bovine, Zebrafish 21931811

Van Duyne, R. et al. Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery. PLoS One 7, e40662 (2012). WB, IHC, Rat, Dog, Pig, Guinea pig, Human, Mouse, Rabbit, Horse, Bovine, Zebrafish 22808228

Protein Accession # NP_073557
Purification Affinity Purified
Nucleotide Accession # NM_022720
Gene Symbol DGCR8
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 85%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 77%
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