Product Number |
ARP40956_P050 |
Product Page |
www.avivasysbio.com/tnrc6a-antibody-n-terminal-region-arp40956-p050.html |
Name |
TNRC6A Antibody - N-terminal region (ARP40956_P050) |
Protein Size (# AA) |
1962 amino acids |
Molecular Weight |
210kDa |
NCBI Gene Id |
27327 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Trinucleotide repeat containing 6A |
Alias Symbols |
GW1, FAME6, GW182, TNRC6, CAGH26 |
Peptide Sequence |
Synthetic peptide located within the following region: RELEAKATKDVERNLSRDLVQEEEQLMEEKKKKKDDKKKKEAAQKKATEQ |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Eulalio,A., (2008) Nat. Struct. Mol. Biol. 15 (4), 346-353 |
Description of Target |
TNRC6A is a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing.This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
Protein Interactions |
TRIP13; CEP250; TRIM65; AGO3; AGO2; AGO1; UBC; SAV1; AGO4; CUL3; UBR5; PABPC1; WNK1; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Enhanced Validation |
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Datasheets/Manuals |
Printable datasheet for anti-TNRC6A (ARP40956_P050) antibody |
Blocking Peptide |
For anti-TNRC6A (ARP40956_P050) antibody is Catalog # AAP40956 (Previous Catalog # AAPS02706) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human TNRC6A |
Uniprot ID |
Q8NDV7 |
Protein Name |
Trinucleotide repeat-containing gene 6A protein |
Publications |
Bukong, T. N., Hou, W., Kodys, K. & Szabo, G. Ethanol facilitates hepatitis C virus replication via up-regulation of GW182 and heat shock protein 90 in human hepatoma cells. Hepatology 57, 70-80 (2013). 22898980 |
Protein Accession # |
NP_055309 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_014494 |
Tested Species Reactivity |
Human |
Gene Symbol |
TNRC6A |
Predicted Species Reactivity |
Human, Mouse, Dog, Horse |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Dog: 93%; Horse: 100%; Human: 100%; Mouse: 100% |
Image 1 | Human MCF-7
| WB Suggested Anti-TNRC6A Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: MCF7 cell lysate |
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