TNRC6A Antibody - N-terminal region (ARP40956_P050)

Data Sheet
 
Product Number ARP40956_P050
Product Page www.avivasysbio.com/tnrc6a-antibody-n-terminal-region-arp40956-p050.html
Name TNRC6A Antibody - N-terminal region (ARP40956_P050)
Protein Size (# AA) 1962 amino acids
Molecular Weight 210kDa
NCBI Gene Id 27327
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Trinucleotide repeat containing 6A
Alias Symbols GW1, FAME6, GW182, TNRC6, CAGH26
Peptide Sequence Synthetic peptide located within the following region: RELEAKATKDVERNLSRDLVQEEEQLMEEKKKKKDDKKKKEAAQKKATEQ
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Eulalio,A., (2008) Nat. Struct. Mol. Biol. 15 (4), 346-353
Description of Target TNRC6A is a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing.This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Interactions TRIP13; CEP250; TRIM65; AGO3; AGO2; AGO1; UBC; SAV1; AGO4; CUL3; UBR5; PABPC1; WNK1;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Enhanced Validation
WBY
SPR
YCHAROS
Datasheets/Manuals Printable datasheet for anti-TNRC6A (ARP40956_P050) antibody
Blocking Peptide For anti-TNRC6A (ARP40956_P050) antibody is Catalog # AAP40956 (Previous Catalog # AAPS02706)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human TNRC6A
Uniprot ID Q8NDV7
Protein Name Trinucleotide repeat-containing gene 6A protein
Publications

Bukong, T. N., Hou, W., Kodys, K. & Szabo, G. Ethanol facilitates hepatitis C virus replication via up-regulation of GW182 and heat shock protein 90 in human hepatoma cells. Hepatology 57, 70-80 (2013). 22898980

Protein Accession # NP_055309
Purification Affinity Purified
Nucleotide Accession # NM_014494
Tested Species Reactivity Human
Gene Symbol TNRC6A
Predicted Species Reactivity Human, Mouse, Dog, Horse
Application WB
Predicted Homology Based on Immunogen Sequence Dog: 93%; Horse: 100%; Human: 100%; Mouse: 100%
Image 1
Human MCF-7
WB Suggested Anti-TNRC6A Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: MCF7 cell lysate
 

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