| Product Number |
ARP40711_P050 |
| Product Page |
www.avivasysbio.com/xpot-antibody-middle-region-arp40711-p050.html |
| Name |
XPOT Antibody - middle region (ARP40711_P050) |
| Protein Size (# AA) |
962 amino acids |
| Molecular Weight |
110kDa |
| NCBI Gene Id |
11260 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Exportin, tRNA (nuclear export receptor for tRNAs) |
| Description |
|
| Alias Symbols |
XPO3 |
| Peptide Sequence |
Synthetic peptide located within the following region: TVLSDQQKANVEAIMLAVMKKLTYDEEYNFENEGEDEAMFVEYRKQLKLL |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Li,S. (2006) RNA Biol 3 (4), 145-149 |
| Description of Target |
XPOT belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. |
| Protein Interactions |
SUMO2; SUMO3; UBC; RNF2; MCMBP; PAPSS1; NFRKB; APEX1; FBXO6; EGFR; IQCB1; CA9; ECT2; TXNL1; USP7; UBD; RAN; CUL5; FBXO25; SIRT7; EBNA-LP; HDAC5; MYC; CAMKK2; CLN3; AIRE; XPO7; NUP153; RANBP2; HDLBP; NUP214; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-XPOT (ARP40711_P050) antibody |
| Blocking Peptide |
For anti-XPOT (ARP40711_P050) antibody is Catalog # AAP40711 (Previous Catalog # AAPY00963) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human XPOT |
| Uniprot ID |
O43592 |
| Protein Name |
Exportin-T |
| Publications |
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals. Elife. 10, NULL (2021) |
| Sample Type Confirmation |
XPOT is supported by BioGPS gene expression data to be expressed in Jurkat |
| Protein Accession # |
NP_009166 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_007235 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
XPOT |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish |
| Application |
IHC, WB, IP |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 75%; Zebrafish: 93% |
| Image 1 | Human Bronchial Epithelial Tissue
 | Rabbit Anti-XPOT Antibody
Catalog Number: ARP40711_P050
Formalin Fixed Paraffin Embedded Tissue: Human Bronchial Epithelial Tissue
Observed Staining: Cytoplasmic and nuclear
Primary Antibody Concentration: 1:100
Other Working Concentrations: 1/600
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec
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| Image 2 |
 | 25 ug of the indicated Human whole cell extracts was loaded onto a 6-18% SDS-PAGE gel. 1 ug/mL of the antibody was used in this experiment. The peptide sequence is present in a 57 kDa isoform.
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