HNRPL Antibody - N-terminal region : FITC (ARP40368_P050-FITC)

• Product Number: ARP40368_P050-FITC
• Name: HNRPL Antibody - N-terminal region : FITC (ARP40368_P050-FITC)
• Protein Size (# AA): 589 amino acids
• Molecular Weight: 65kDa
• Conjugation: FITC: Fluorescein Isothiocyanate
• NCBI Gene Id: 3191
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Heterogeneous nuclear ribonucleoprotein L
• Alias Symbols: HNRPL, hnRNP-L, P/OKcl.14
• Peptide Sequence: Synthetic peptide located within the following region: AAGGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYV
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Reference: Guang,S., (2005) Mol. Cell. Biol. 25 (15), 6303-6313
• Description of Target: Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions.Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.
• Protein Interactions: TP53; FUS; TRIM68; SUMO2; SUMO3; IVNS1ABP; UBC; MDM2; RPA3; RPA2; RPA1; ILF3; HNRNPA2B1; EED; VHL; VEGFA; RNF2; NEDD4; ITCH; FBXO6; HMGA1; vif; TP63; UBL4A; WHSC1; VCAM1; ITGA4; IL7R; IFIT3; IFIT2; FN1; DAB2; CSNK2A1; EIF4A3; MAGOH; HNRNPA3; NPLOC4; LSM14
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Blocking Peptide: For anti-HNRNPL (ARP40368_P050-FITC) antibody is Catalog # AAP40368 (Previous Catalog # AAPP22112)
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HNRPL
• Uniprot ID: P14866
• Protein Name: Heterogeneous nuclear ribonucleoprotein L
• Sample Type Confirmation:

  HNRNPL is strongly supported by BioGPS gene expression data to be expressed in Jurkat

• Protein Accession #: NP_001524
• Purification: Affinity Purified
• Nucleotide Accession #: NM_001533
• Gene Symbol: HNRNPL
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Application: IF, IP, WB, IHC
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
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