| Product Number |
ARP40165_P050 |
| Product Page |
www.avivasysbio.com/insig2-antibody-n-terminal-region-arp40165-p050.html |
| Name |
INSIG2 Antibody - N-terminal region (ARP40165_P050) |
| Protein Size (# AA) |
225 amino acids |
| Molecular Weight |
25kDa |
| NCBI Gene Id |
51141 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Insulin induced gene 2 |
| Alias Symbols |
INSIG-2 |
| Peptide Sequence |
Synthetic peptide located within the following region: MAEGETESPGPKKCGPYISSVTSQSVNLMIRGVVLFFIGVFLALVLNLLQ |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Li,C.G., (2008) Int. J. Cancer 123 (2), 273-282 |
| Description of Target |
INSIG2 is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
RNF5; HMGCR; SCAP; SREBF1; RNF139; UBQLN1; UBQLN2; FAF2; ADRM1; PSMD14; BAG6; VCP; UBC; RPN1; PSMD13; PSMD12; PSMD11; PSMD4; PSMC6; PSMC5; PSMC3; PSMC2; PSMB3; PSMB1; PSMA7; PSMA2; LGALS7; JUP; INSIG1; HSPA8; HSPA6; HSPA5; HSPA1A; ENO1; DSP; AMFR; SREBF2; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-INSIG2 (ARP40165_P050) antibody |
| Blocking Peptide |
For anti-INSIG2 (ARP40165_P050) antibody is Catalog # AAP40165 (Previous Catalog # AAPY00799) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human INSIG2 |
| Uniprot ID |
Q9Y5U4 |
| Protein Name |
Insulin-induced gene 2 protein |
| Publications |
Yu, Z. et al. Rapamycin and Dietary Restriction Induce Metabolically Distinctive Changes in Mouse Liver. J. Gerontol. A. Biol. Sci. Med. Sci. glu053- (2014). doi:10.1093/gerona/glu053 24755936 |
| Protein Accession # |
NP_057217 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_016133 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
INSIG2 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Goat, Horse, Pig, Rabbit, Sheep |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 92%; Goat: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Pig: 92%; Rabbit: 100%; Rat: 92%; Sheep: 100% |
| Image 1 | Human Brain
 | WB Suggested Anti-INSIG2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human brain |
|
