JMJD3 Antibody - middle region (ARP40102_T100)

Data Sheet
 
Product Number ARP40102_T100
Product Page www.avivasysbio.com/jmjd3-antibody-middle-region-arp40102-t100.html
Name JMJD3 Antibody - middle region (ARP40102_T100)
Protein Size (# AA) 1643 amino acids
Molecular Weight 177kDa
NCBI Gene Id 23135
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name Lysine (K)-specific demethylase 6B
Description
Alias Symbols JMJD3, NEDCFSA
Peptide Sequence Synthetic peptide located within the following region: AGLQGVVVLEQYRTEELAQAYDAFTLVRARRARGQRRRALGQAAGTGFGS
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Description of Target JMJD3 is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
Protein Interactions WDR5; ASH2L; RBBP5; UBC; TK1; CSNK2B; HIST1H3A; WAS; SMAD3; SMAD2; SMAD4; SMAD1;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-KDM6B (ARP40102_T100) antibody
Blocking Peptide For anti-KDM6B (ARP40102_T100) antibody is Catalog # AAP40102 (Previous Catalog # AAPP22940)
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human JMJD3
Uniprot ID O15054
Protein Name Lysine-specific demethylase 6B
Protein Accession # AAH09994
Purification Protein A purified
Nucleotide Accession # NM_001080424
Tested Species Reactivity Human
Gene Symbol KDM6B
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
Image 1
Human HepG2
WB Suggested Anti-JMJD3 Antibody Titration: 1.25ug/ml
Positive Control: HepG2 cell lysate
Image 2
Human Jurkat Whole Cell
Host: Rabbit
Target Name: KDM6B
Sample Tissue: Human Jurkat Whole Cell
Antibody Dilution: 5ug/ml
Image 3
HepG2
Host: Rabbit
Target Name: JMJD3
Sample Type: HepG2
Lane A: Primary Antibody
Lane B: Primary Antibody + Blocking Peptide
Primary Antibody Concentration: 2.5ug/mL
Peptide Concentration: 2.0ug/mL
Lysate Quantity: 25ug/lane
Gel Concentration: 6%-18%
 

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