Product Number |
ARP39026_P050 |
Product Page |
www.avivasysbio.com/cnot7-antibody-n-terminal-region-arp39026-p050.html |
Name |
CNOT7 Antibody - N-terminal region (ARP39026_P050) |
Protein Size (# AA) |
262 amino acids |
Molecular Weight |
30kDa |
Subunit |
7 |
NCBI Gene Id |
29883 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
CCR4-NOT transcription complex, subunit 7 |
Alias Symbols |
CAF1, CAF-1, Caf1a, hCAF-1 |
Peptide Sequence |
Synthetic peptide located within the following region: TEFPGVVARPIGEFRSNADYQYQLLRCNVDLLKIIQLGLTFMNEQGEYPP |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Kimura,K., (2006) Genome Res. 16 (1), 55-65 |
Description of Target |
CNOT7 binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs.The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms. |
Protein Interactions |
FBXW11; TOB2; BTG2; FOXC2; UBC; BAG3; CNOT6; AGO2; AGO1; EPAS1; APP; ELAVL1; BTG1; Cnot3; HOXD4; IKBKG; BTG3; TOB1; CDK6; CDK4; CDK2; CDK1; PABPC1; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-CNOT7 (ARP39026_P050) antibody |
Blocking Peptide |
For anti-CNOT7 (ARP39026_P050) antibody is Catalog # AAP39026 (Previous Catalog # AAPS03806) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human CNOT7 |
Uniprot ID |
Q9UIV1 |
Protein Name |
CCR4-NOT transcription complex subunit 7 |
Publications |
Maragozidis, P. et al. Alterations of deadenylase expression in acute leukemias: evidence for poly(a)-specific ribonuclease as a potential biomarker. Acta Haematol. 128, 39-46 (2012). 22614729 |
Sample Type Confirmation |
CNOT7 is supported by BioGPS gene expression data to be expressed in HepG2 |
Protein Accession # |
NP_037486 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_013354 |
Tested Species Reactivity |
Human |
Gene Symbol |
CNOT7 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 79%; Zebrafish: 100% |
Image 1 | Human HepG2
| WB Suggested Anti-CNOT7 Antibody Titration: 0.2-1 ug/ml Positive Control: HepG2 cell lysateCNOT7 is supported by BioGPS gene expression data to be expressed in HepG2 |
|
Image 2 | Human Heart
| Rabbit Anti-CNOT7 antibody
Catalog Number: ARP39026
Paraffin Embedded Tissue: Human Heart
cell Cellular Data: cardiac cell
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X |
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