PPARGC1A Antibody - N-terminal region (ARP39015_P050)

• Product Number: ARP39015_P050
• Name: PPARGC1A Antibody - N-terminal region (ARP39015_P050)
• Protein Size (# AA): 798 amino acids
• Molecular Weight: 91 kDa
• NCBI Gene Id: 10891
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
• Alias Symbols: LEM6, PGC1, PGC1A, PGC-1v, PPARGC1, PGC-1alpha, PGC-1(alpha)
• Peptide Sequence: Synthetic peptide located within the following region: MAWDMCNQDSESVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDS
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Description of Target: The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
• Protein Interactions: NRIP1; SUMO1; UBE2I; UBC; SIRT1; PPARG; PRKAA1; KAT2A; EGFR; CDK6; CAPNS1; PARK7; PIAS1; SFPQ; ESRRG; RNF2; TP53; HNF4A; CREBZF; NR3C1; ESRRA; RNF34; NR1I2; ESR2; BCL6; SF1; NR5A2; MYEF2; NCOA6; IQGAP1; MYOD1; EP300; LRPPRC; THRB; MYBBP1A; MED1; NR1I3; NC
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Enhanced Validation: Relative Expression (Western Blot)
  
• Other Applications Image 1 Data: WB Suggested Anti-PPARGC1A antibody
  Titration: 0.06 ug/ml
  Positive Control: SH-SY5Y Neuroblastoma Cells
  
• Blocking Peptide: For anti-PPARGC1A (ARP39015_P050) antibody is Catalog # AAP39015 (Previous Catalog # AAPS03708)
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PPARGC1A
• Uniprot ID: Q9UBK2
• Protein Name: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
• Publications:

  Tumor protein Tctp regulates axon development in the embryonic visual system. Development. 143, 1134-48 (2016). 26903505

• Protein Accession #: NP_037393
• Purification: Affinity Purified
• Nucleotide Accession #: NM_013261
• Tested Species Reactivity: Human
• Gene Symbol: PPARGC1A
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 90%
• Image 1: Human ACHN
  
  WB Suggested Anti-PPARGC1A Antibody Titration: 0.2-1 ug/ml
  ELISA Titer: 1:312500
  Positive Control: ACHN cell lysate