Product Number |
ARP38977_P050 |
Product Page |
www.avivasysbio.com/hbp1-antibody-middle-region-arp38977-p050.html |
Name |
HBP1 Antibody - middle region (ARP38977_P050) |
Protein Size (# AA) |
514 amino acids |
Molecular Weight |
58kDa |
NCBI Gene Id |
26959 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
HMG-box transcription factor 1 |
Alias Symbols |
FLJ16340 |
Peptide Sequence |
Synthetic peptide located within the following region: SVILGDRWKKMKNEERRMYTLEAKALAEEQKRLNPDCWKRKRTNSGSQQH |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Paulson,K.E., (2007) Cancer Res. 67 (13), 6136-6145 |
Description of Target |
HBP1 is a transcriptional repressor that binds to the promoter region of target genes. This protein plays a role in the regulation of the cell cycle and of the Wnt pathway. It binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter, HBP1 is enhanced by interaction with RB1. The protein also can disrupt the interaction between DNA and TCF4. |
Protein Interactions |
FBXW11; UBC; TMEM37; SMAD1; ZNF212; KIAA1279; EWSR1; CD2AP; EP300; CREBBP; MYC; ANKRD2; SIN3A; SAP30; TCF4; HDAC1; RBL2; RB1; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-HBP1 (ARP38977_P050) antibody |
Blocking Peptide |
For anti-HBP1 (ARP38977_P050) antibody is Catalog # AAP38977 (Previous Catalog # AAPS05408) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human HBP1 |
Uniprot ID |
O60381 |
Protein Name |
HMG box-containing protein 1 |
Publications |
Li, H., Bian, C., Liao, L., Li, J. & Zhao, R. C. miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1. Breast Cancer Res. Treat. 126, 565-75 (2011). 20505989
Wang, W., Pan, K., Chen, Y., Huang, C. & Zhang, X. The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression. Nucleic Acids Res. 40, 981-95 (2012). 21967847 |
Sample Type Confirmation |
HBP1 is supported by BioGPS gene expression data to be expressed in HeLa |
Protein Accession # |
NP_036389 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_012257 |
Tested Species Reactivity |
Human |
Gene Symbol |
HBP1 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92% |
Image 1 | Human HeLa
| WB Suggested Anti-HBP1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Hela cell lysateHBP1 is supported by BioGPS gene expression data to be expressed in HeLa |
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Image 2 | HeLa Cell Lysate, 293T Cell Lysate
| Host: Rabbit Target: HBP1 Positive control (+): HeLa Cell Lysate (HL) Negative control (-): 293T Cell Lysate (2T) Antibody concentration: 0.5ug/ml |
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