| Product Number |
ARP38532_P050 |
| Product Page |
www.avivasysbio.com/hmgn1-antibody-middle-region-arp38532-p050.html |
| Name |
HMGN1 Antibody - middle region (ARP38532_P050) |
| Protein Size (# AA) |
100 amino acids |
| Molecular Weight |
11kDa |
| NCBI Gene Id |
3150 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
High mobility group nucleosome binding domain 1 |
| Alias Symbols |
HMG14 |
| Peptide Sequence |
Synthetic peptide located within the following region: QTKGKRGAKGKQAEVANQETKEDLPAENGETKTEESPASDEAGEKEAKSD |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Zhu,N. (2007) Mol. Cell. Biol. 27 (24), 8859-8873 |
| Description of Target |
Chromosomal protein HMG14 (HMGN1) and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
UBC; RPS6KA3; PRKCA; PRKACG; SLC38A3; PPP1CC; LIG4; PPIP5K1; TERF2; SPP1; POLR2A; ERCC8; HDGF; EP300; BTG2; ERCC6; NFE2; RPS6KA5; RPS6KA4; PRKACA; YWHAZ; HMGN1; HMGN2; IRF2; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-HMGN1 (ARP38532_P050) antibody |
| Blocking Peptide |
For anti-HMGN1 (ARP38532_P050) antibody is Catalog # AAP38532 (Previous Catalog # AAPP20723) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human HMGN1 |
| Uniprot ID |
Q6NSG7 |
| Protein Name |
High-mobility group nucleosome binding domain 1 EMBL AAH70154.1 |
| Publications |
Lane, A. A. et al. Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. Nat. Genet. 46, 618-23 (2014). 24747640 |
| Protein Accession # |
NP_004956 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_004965 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
HMGN1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 79%; Pig: 100%; Rabbit: 93%; Rat: 79% |
| Image 1 | Human heart
 | WB Suggested Anti-HMGN1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human heart |
|
