ATF4 Antibody - C-terminal region (ARP38067_T100)

Data Sheet
 
Product Number ARP38067_T100
Product Page www.avivasysbio.com/atf4-antibody-c-terminal-region-arp38067-t100.html
Name ATF4 Antibody - C-terminal region (ARP38067_T100)
Protein Size (# AA) 351 amino acids
Molecular Weight 39kDa
NCBI Gene Id 468
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name Activating transcription factor 4 (tax-responsive enhancer element B67)
Description
Alias Symbols CREB2, TXREB, CREB-2, TAXREB67
Peptide Sequence Synthetic peptide located within the following region: EQNKTAATRYRQKKRAEQEALTGECKELEKKNEALKERADSLAKEIQYLK
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Lassot,I., et al., (2005) J. Biol. Chem. 280 (50), 41537-41545
Description of Target ATF4s a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.
Protein Interactions GPS2; GOLGA1; EP300; CEBPG; GOLGA8F; GOLGA8EP; GCC1; TRIB3; CCDC106; LDOC1; FBXW11; NDC80; BTRC; BFSP2; DDIT3; CREBBP; NEK6; JUN; FOS; ATF2; CEBPE; CEBPA; ATF4; ATF3; BATF2; CREBZF; BATF3; BATF; CREB3; MAFB; FOSL1; NFE2L2; NFE2; MAF; UBC; TGM2; RPS6; MAP2
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-ATF4 (ARP38067_T100) antibody
Blocking Peptide For anti-ATF4 (ARP38067_T100) antibody is Catalog # AAP38067 (Previous Catalog # AAPP20241)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human ATF4
Uniprot ID P18848
Protein Name Cyclic AMP-dependent transcription factor ATF-4
Publications

Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa. PLoS One. 10, e0115723 (2015). 25695253

Sample Type Confirmation

ATF4 is supported by BioGPS gene expression data to be expressed in Jurkat

Protein Accession # NP_001666
Purification Protein A purified
Nucleotide Accession # NM_001675
Tested Species Reactivity Human
Gene Symbol ATF4
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Sheep, Yeast
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rat: 93%; Sheep: 93%; Yeast: 82%
Image 1
Human Jurkat
WB Suggested Anti-ATF4 Antibody Titration: 5.0ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysateATF4 is supported by BioGPS gene expression data to be expressed in Jurkat
 

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