| Product Number |
ARP38058_T100-HRP |
| Product Page |
www.avivasysbio.com/id4-antibody-n-terminal-region-hrp-arp38058-t100-hrp.html |
| Name |
ID4 Antibody - N-terminal region : HRP (ARP38058_T100-HRP) |
| Protein Size (# AA) |
161 amino acids |
| Molecular Weight |
17kDa |
| Conjugation |
HRP: Horseradish Peroxidase |
| NCBI Gene Id |
3400 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein |
| Alias Symbols |
IDB4, bHLHb27 |
| Peptide Sequence |
Synthetic peptide located within the following region: MKAVSPVRPSGRKAPSGCGGGELALRCLAEHGHSLGGSAAAAAAAAAARC |
| Product Format |
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6. |
| Reference |
Yu,L., et al., (2005) Nat. Genet. 37 (3), 265-274 |
| Description of Target |
Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins (Pagliuca et al., 1995).[supplied by OMIM]. |
| Protein Interactions |
TCF3; TCF4; ID3; MYOD1; HES1; |
| Reconstitution and Storage |
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Datasheets/Manuals |
Printable datasheet for anti-ID4 (ARP38058_T100-HRP) antibody |
| Blocking Peptide |
For anti-ID4 (ARP38058_T100-HRP) antibody is Catalog # AAP38058 (Previous Catalog # AAPP20232) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human ID4 |
| Uniprot ID |
P47928 |
| Protein Name |
DNA-binding protein inhibitor ID-4 |
| Publications |
Melcher, R. et al. LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability. Carcinogenesis 32, 636-42 (2011). WB, IHC, Pig, Dog, Rat, Mouse, Human, Zebrafish 21297112 |
| Protein Accession # |
NP_001537 |
| Nucleotide Accession # |
NM_001546 |
| Gene Symbol |
ID4 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Dog, Pig, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Dog: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 85% |
| Image 1 | |
