| Product Number |
ARP37963_P050 |
| Product Page |
www.avivasysbio.com/ercc3-antibody-n-terminal-region-arp37963-p050.html |
| Name |
ERCC3 Antibody - N-terminal region (ARP37963_P050) |
| Protein Size (# AA) |
782 amino acids |
| Molecular Weight |
89kDa |
| NCBI Gene Id |
2071 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Excision repair cross-complementing rodent repair deficiency, complementation group 3 |
| Description |
|
| Alias Symbols |
XPB, BTF2, Ssl2, TTD2, GTF2H, RAD25, TFIIH |
| Peptide Sequence |
Synthetic peptide located within the following region: MGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPSAAGKQVDESG |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. |
| Protein Interactions |
XIAP; CEP70; UBC; rev; SRPK2; CDK7; TP53; E2F1; CDK8; CCNC; GTF2H5; ERCC2; MSANTD2; UVSSA; POLR2C; KPNA3; RAD52; MMS19; SIX5; GTF2H4; GTF2H3; GTF2H1; tat; COPS2; GTF2H2; NEDD8; ERCC6; POLR2A; AR; CCNH; MYC; MNAT1; ZSCAN1; ATF7IP; GCN1L1; ERCC5; BCR; PSMC5 |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-ERCC3 (ARP37963_P050) antibody |
| Blocking Peptide |
For anti-ERCC3 (ARP37963_P050) antibody is Catalog # AAP37963 (Previous Catalog # AAPP23267) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human ERCC3 |
| Uniprot ID |
P19447 |
| Protein Name |
TFIIH basal transcription factor complex helicase XPB subunit |
| Publications |
A Recurrent ERCC3 Truncating Mutation Confers Moderate Risk for Breast Cancer. Cancer Discov. 6, 1267-1275 (2016). 27655433 |
| Sample Type Confirmation |
ERCC3 is supported by BioGPS gene expression data to be expressed in HCT15 |
| Protein Accession # |
NP_000113 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_000122 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
ERCC3 |
| Predicted Species Reactivity |
Human, Rat, Cow, Dog, Guinea Pig, Pig, Rabbit, Yeast, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 86%; Dog: 86%; Guinea Pig: 79%; Human: 100%; Pig: 93%; Rabbit: 79%; Rat: 79%; Yeast: 90%; Zebrafish: 79% |
| Image 1 | Human HCT15
 | WB Suggested Anti-ERCC3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HCT15 cell lysateERCC3 is supported by BioGPS gene expression data to be expressed in HCT15 |
|
