MCM8 Antibody - C-terminal region (ARP36668_P050)

Data Sheet
 
Product Number ARP36668_P050
Product Page www.avivasysbio.com/mcm8-antibody-c-terminal-region-arp36668-p050.html
Name MCM8 Antibody - C-terminal region (ARP36668_P050)
Protein Size (# AA) 840 amino acids
Molecular Weight 94kDa
NCBI Gene Id 84515
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Minichromosome maintenance complex component 8
Alias Symbols POF10, C20orf154, dJ967N21.5
Peptide Sequence Synthetic peptide located within the following region: IRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQH
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Clarke,C.A. Biochem. J. 388 (PT 2), 705-712 (2005)
Description of Target MCM8 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Protein Interactions MCMBP; MCM4; MCM6; MCM7; ORC2; CDC6;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-MCM8 (ARP36668_P050) antibody
Blocking Peptide For anti-MCM8 (ARP36668_P050) antibody is Catalog # AAP36668 (Previous Catalog # AAPS06309)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human MCM8
Uniprot ID Q9UJA3
Protein Name DNA helicase MCM8
Publications

Ono, A. et al. Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues. Hum. Pathol. 40, 41-9 (2009). 18755499

Protein Accession # NP_115874
Purification Affinity Purified
Nucleotide Accession # NM_032485
Tested Species Reactivity Human
Gene Symbol MCM8
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
Image 1
Human 721_B
WB Suggested Anti-MCM8 Antibody Titration: 0.2-1 ug/ml
Positive Control: 721_B cell lysate
Image 2
Human Intestine
Human Intestine
 

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