| Product Number |
ARP36372_P050 |
| Product Page |
www.avivasysbio.com/bat1-antibody-c-terminal-region-arp36372-p050.html |
| Name |
BAT1 Antibody - C-terminal region (ARP36372_P050) |
| Protein Size (# AA) |
428 amino acids |
| Molecular Weight |
47kDa |
| NCBI Gene Id |
7919 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B |
| Alias Symbols |
BAT1, UAP56, D6S81E |
| Peptide Sequence |
Synthetic peptide located within the following region: YDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNI |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Allcock,R.J., et al., (2001) Genes Cells 6 (5), 487-494 |
| Description of Target |
BAT1 is a member of the DEAD protein family of ATP-dependent RNA helicases. Members of this family are involved in a number of cellular functions including initiation of translation, RNA splicing, and ribosome assembly. A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This protein is a negative regulator of inflammation. It is also thought to be a translation initiation factor. This gene is a strong candidate gene for rheumatoid arthritis. There are multiple alternatively spliced transcript variants known for this gene but only two have been fully described. Both of these variants encode the same isoform. This gene has been found to have multiple polyadenylation sites. |
| Protein Interactions |
THOC3; THOC2; ALYREF; NCBP1; STAU1; SHFM1; UBC; MDM2; WWOX; SUZ12; EED; RNF2; BMI1; RBBP4; C12orf10; NDRG1; HSPD1; GSR; SRPK2; UBD; VCAM1; ITGA4; IL7R; FN1; ATF2; BARD1; WIBG; MAGOHB; WDR74; VPS33B; LSM4; THOC1; RBM8A; DHX38; TXNL1; UBE3A; RPS7; EIF4A2; R |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-DDX39B (ARP36372_P050) antibody |
| Blocking Peptide |
For anti-DDX39B (ARP36372_P050) antibody is Catalog # AAP36372 (Previous Catalog # AAPP08430) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human BAT1 |
| Uniprot ID |
Q13838 |
| Protein Name |
Spliceosome RNA helicase DDX39B |
| Publications |
Bouley, J. et al. Proteomic analysis of BRCA1-depleted cell line reveals a putative role for replication protein A2 up-regulation in BRCA1 breast tumor development. Proteomics. Clin. Appl. 4, 489-98 (2010). 21137066 |
| Sample Type Confirmation |
DDX39B is supported by BioGPS gene expression data to be expressed in Jurkat |
| Protein Accession # |
NP_542165 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_080598 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
DDX39B |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93% |
| Image 1 | Human Jurkat
 | WB Suggested Anti-BAT1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: Jurkat cell lysateDDX39B is supported by BioGPS gene expression data to be expressed in Jurkat |
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