| Product Number |
ARP35696_P050 |
| Product Page |
www.avivasysbio.com/eed-antibody-n-terminal-region-arp35696-p050.html |
| Name |
Eed Antibody - N-terminal region (ARP35696_P050) |
| Protein Size (# AA) |
441 amino acids |
| Molecular Weight |
50kDa |
| NCBI Gene Id |
13626 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Embryonic ectoderm development |
| Alias Symbols |
l7, l(7), lusk, l7Rn5, l(7)5Rn |
| Peptide Sequence |
Synthetic peptide located within the following region: AKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKS |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
Eed is a polycomb group (PcG) protein. It is a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Eed plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Eed is required for stable maintenance of XCI in both embryonic and extra-embryonic tissues. Eed may prevent transcriptional activation of facultative heterochromatin during differentiation. Eed is required for development of secondary trophoblast giant cells during placental development. Eed may regulate hippocampal synaptic plasticity in the developing brain. |
| Protein Interactions |
Ezh2; Suz12; Rab3gap1; Ddx47; Nop10; Nip7; Bola2; Tmem14c; Uqcr10; Eif3f; Cbwd1; Smc5; Etf1; Svil; Fbxo11; Srsf7; Safb; Safb2; Abcf1; Bag6; C330027C09Rik; Pak2; Pphln1; Ttll12; Sun2; Tomm22; Eif3l; E430025E21Rik; Eny2; Dcaf13; Trio; Ccar2; Fermt2; Vps41; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-Eed (ARP35696_P050) antibody |
| Blocking Peptide |
For anti-Eed (ARP35696_P050) antibody is Catalog # AAP35696 |
| Uniprot ID |
Q921E6 |
| Protein Name |
Polycomb protein EED |
| Protein Accession # |
NP_068676 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_021876 |
| Tested Species Reactivity |
Mouse |
| Gene Symbol |
Eed |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93% |
| Image 1 | Mouse Brain
 | WB Suggested Anti-Eed Antibody
Titration: 1.0 ug/ml
Positive Control: Mouse Brain |
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