Product Number |
ARP35459_T100-FITC |
Product Page |
www.avivasysbio.com/kcnq2-antibody-middle-region-fitc-arp35459-t100-fitc.html |
Name |
KCNQ2 Antibody - middle region : FITC (ARP35459_T100-FITC) |
Protein Size (# AA) |
393 amino acids |
Molecular Weight |
43kDa |
Conjugation |
FITC: Fluorescein Isothiocyanate |
NCBI Gene Id |
3785 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Potassium voltage-gated channel, KQT-like subfamily, member 2 |
Alias Symbols |
EBN, BFNC, DEE7, EBN1, ENB1, HNSPC, KV7.2, KCNA11 |
Peptide Sequence |
Synthetic peptide located within the following region: GNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYI |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer. |
Reference |
Tang,B., et al., (2004) J. Neurol. Sci. 221 (1-2), 31-34 |
Description of Target |
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by the KCNQ2 gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). |
Protein Interactions |
ARIH2; KCNQ3; PRKCA; CALM3; CALM1; CALM2; KCNQ1; |
Reconstitution and Storage |
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
Datasheets/Manuals |
Printable datasheet for anti-KCNQ2 (ARP35459_T100-FITC) antibody |
Blocking Peptide |
For anti-KCNQ2 (ARP35459_T100-FITC) antibody is Catalog # AAP35459 (Previous Catalog # AAPP07278) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human KCNQ2 |
Uniprot ID |
Q5VYU0 |
Publications |
Zhang, H. et al. Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents. Neuroscience 254, 70-9 (2013). WB, Human, Mouse, Rat, Bovine, Dog, Horse, Guinea pig, Zebrafish, Rabbit 24036375 |
Protein Accession # |
NP_742107 |
Nucleotide Accession # |
NM_172109 |
Gene Symbol |
KCNQ2 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 93% |
Image 1 | |