Product Number |
ARP35459_T100 |
Product Page |
www.avivasysbio.com/kcnq2-antibody-middle-region-arp35459-t100.html |
Name |
KCNQ2 Antibody - middle region (ARP35459_T100) |
Protein Size (# AA) |
393 amino acids |
Molecular Weight |
43kDa |
NCBI Gene Id |
3785 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
Potassium voltage-gated channel, KQT-like subfamily, member 2 |
Description |
|
Alias Symbols |
EBN, BFNC, DEE7, EBN1, ENB1, HNSPC, KV7.2, KCNA11 |
Peptide Sequence |
Synthetic peptide located within the following region: GNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYI |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Tang,B., et al., (2004) J. Neurol. Sci. 221 (1-2), 31-34 |
Description of Target |
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by the KCNQ2 gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). |
Protein Interactions |
ARIH2; KCNQ3; PRKCA; CALM3; CALM1; CALM2; KCNQ1; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-KCNQ2 (ARP35459_T100) antibody |
Blocking Peptide |
For anti-KCNQ2 (ARP35459_T100) antibody is Catalog # AAP35459 (Previous Catalog # AAPP07278) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human KCNQ2 |
Uniprot ID |
Q5VYU0 |
Publications |
Functional responses of the hippocampus to hyperexcitability depend on directed, neuron-specific KCNQ2 K+ channel plasticity. Hippocampus. 30, 435-455 (2020) 31621989
Zhang, H. et al. Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents. Neuroscience 254, 70-9 (2013). 24036375 |
Protein Accession # |
NP_742107 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_172109 |
Tested Species Reactivity |
Human, Mouse |
Gene Symbol |
KCNQ2 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 93% |
Image 1 | Mouse Skeletal Muscle
| Host: Mouse Target Name: KCNQ2 Sample Tissue: Mouse Skeletal Muscle Antibody Dilution: 1ug/ml |
|
Image 2 | Human HepG2
| WB Suggested Anti-KCNQ2 Antibody Titration: 1.25ug/ml ELISA Titer: 1:62500 Positive Control: HepG2 cell lysate |
|
Image 3 | Human kidney
| Human kidney |
|