TRPA1 Antibody - middle region (ARP35205_P050)

• Product Number: ARP35205_P050
• Name: TRPA1 Antibody - middle region (ARP35205_P050)
• Protein Size (# AA): 1119 amino acids
• Molecular Weight: 127 kDa
• NCBI Gene Id: 8989
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Transient receptor potential cation channel, subfamily A, member 1
• Description:
  View product citations for TRPA1 Antibody - middle region (ARP35205_P050) on CiteAb
• Alias Symbols: FEPS, FEPS1, ANKTM1
• Peptide Sequence: Synthetic peptide located within the following region: KCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLAL
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Chen,J., (2008) J. Neurosci. 28 (19), 5063-5071
• Description of Target: The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in sig
• Protein Interactions: UBC; CYLD;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Enhanced Validation:

  WB	Y
  SPR
  YCHAROS

• Blocking Peptide: For anti-TRPA1 (ARP35205_P050) antibody is Catalog # AAP35205 (Previous Catalog # AAPP23891)
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TRPA1
• Uniprot ID: O75762
• Protein Name: Transient receptor potential cation channel subfamily A member 1
• Publications:

  Pierce, A. N., Ryals, J. M., Wang, R. & Christianson, J. A. Vaginal hypersensitivity and hypothalamic-pituitary-adrenal axis dysfunction as a result of neonatal maternal separation in female mice. Neuroscience 263, 216-30 (2014). 24462609

  Rohn, T. T., Catlin, L. W., Coonse, K. G. & Habig, J. W. Identification of an amino-terminal fragment of apolipoprotein E4 that localizes to neurofibrillary tangles of the Alzheimer’s disease brain. Brain Res. 1475, 106-15 (2012). 22905134

  TRPA1 mediates damage of the retina induced by ischemia and reperfusion in mice. Cell Death Dis. 11, 633 (2020). 32801314

  TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress. Brain. 139, 1361-77 (2016). 26984186

  TRPA1 receptor is upregulated in human oral lichen planus. Oral Dis. 23, 189-198 (2017). 27718297

• Protein Accession #: NP_015628
• Purification: Affinity Purified
• Nucleotide Accession #: NM_007332
• Tested Species Reactivity: Human, Mouse, Rat
• Gene Symbol: TRPA1
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast
• Application: IHC, WB, IF
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 90%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Yeast: 100%
• Image 1: Mouse
  
  Sample Type:
  Section of TRPM8-GFP transgenic mouse trigeminal ganglia
  Primary Antibody Dilution:
  1:250
  Secondary Antibody:
  Goat Anti-Rabbit Alexa-Fluor 594
  Secondary Antibody Dilution:
  1:1000
  Color/Signal Descriptions:
  TRPA1: Red TRPM8-GFP:: Green
  Gene Name:
  TRPA1
  Submitted by:
  Dr. Daniel McCoy, USC
• Image 2: Human THP-1 Whole Cell
  
  Host: Rabbit
  Target Name: TRPA1
  Sample Tissue: Human THP-1 Whole Cell
  Antibody Dilution: 1ug/ml
• Image 3: Rat sensory ganglia
  
  Immunohistochemistry with rat sensory ganglia tissue