Product Number |
ARP34934_P050 |
Product Page |
www.avivasysbio.com/scn5a-antibody-n-terminal-region-arp34934-p050.html |
Name |
SCN5A Antibody - N-terminal region (ARP34934_P050) |
Protein Size (# AA) |
2015 amino acids |
Molecular Weight |
227kDa |
Subunit |
alpha |
NCBI Gene Id |
6331 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Sodium channel, voltage-gated, type V, alpha subunit |
Alias Symbols |
HB1, HB2, HH1, IVF, VF1, HBBD, ICCD, LQT3, SSS1, CDCD2, CMD1E, CMPD2, PFHB1, Nav1.5 |
Peptide Sequence |
Synthetic peptide located within the following region: SEADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALH |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Van (2008) Heart Rhythm 5 (5), 712-715 |
Description of Target |
SCN5A is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. |
Protein Interactions |
CALM1; CAV3; ALB; Nedd4; WWP2; UBC; SNTG2; NEDD4L; DLG2; INADL; DLG4; RGS3; SNTA1; DLG1; RGS2; SCN5A; SNTB2; SNTB1; DLG3; CBL; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-SCN5A (ARP34934_P050) antibody |
Blocking Peptide |
For anti-SCN5A (ARP34934_P050) antibody is Catalog # AAP34934 (Previous Catalog # AAPP06157) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human SCN5A |
Uniprot ID |
Q14524 |
Protein Name |
Sodium channel protein type 5 subunit alpha |
Publications |
Matsushita, N. et al. Nicorandil improves electrical remodelling, leading to the prevention of electrically induced ventricular tachyarrhythmia in a mouse model of desmin-related cardiomyopathy. Clin. Exp. Pharmacol. Physiol. 41, 89-97 (2014). 24117876 |
Protein Accession # |
NP_000326 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_000335 |
Tested Species Reactivity |
Human |
Gene Symbol |
SCN5A |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
WB, IHC |
Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 77% |
Image 1 | Human Fetal Muscle
| Host: Rabbit Target Name: SCN5A Sample Type: Human Fetal Muscle Antibody Dilution: 1.0ug/ml |
|
Image 2 | heart
| Rabbit Anti-SCN5A Antibody Catalog Number: ARP34934_P050 Formalin Fixed Paraffin Embedded Tissue: Human Adult heart Observed Staining: Membrane Primary Antibody Concentration: 1:100 Secondary Antibody: Donkey anti-Rabbit-Cy2/3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 2.0 sec Protocol located in Reviews and Data. |
|
Image 3 | Human Muscle
| WB Suggested Anti-SCN5A Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: Human Muscle |
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