CNBP Antibody - N-terminal region (ARP34815_P050)

• Product Number: ARP34815_P050
• Name: CNBP Antibody - N-terminal region (ARP34815_P050)
• Protein Size (# AA): 177 amino acids
• Molecular Weight: 19 kDa
• NCBI Gene Id: 7555
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: CCHC-type zinc finger, nucleic acid binding protein
• Alias Symbols: DM2, ZNF9, CNBP1, PROMM, RNF163, ZCCHC22
• Peptide Sequence: Synthetic peptide located within the following region: SSNECFKCGRSGHWARECPTGGGRGRGMRSRGRGGFTSDRGFQFVSSSLP
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Gerbasi,V.R. (2007) Mol. Cell Proteomics 6 (6), 1049-1058
• Description of Target: CNBP is a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene.This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
• Protein Interactions: UBC; EZH2; BMI1; SUZ12; RNF2; BZW2; FERMT2; PFAS; EIF6; HSPA9; DFFA; MAPK14; PAN2; VCAM1; ITGA4; KCND3; Mis12; Cnbp; ZWINT; MYH4; FKTN; PCBP2; RPL31; HNRNPA3; BRIX1; APOBEC3C; RBMX; RSL1D1; RPL36; HNRNPUL1; EBNA1BP2; IGF2BP3; IGF2BP1; SYNCRIP; HNRNPR; DAP
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Enhanced Validation: Relative Expression (Western Blot)
  
• Blocking Peptide: For anti-CNBP (ARP34815_P050) antibody is Catalog # AAP34815 (Previous Catalog # AAPP06023)
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CNBP
• Uniprot ID: P62633
• Protein Name: Cellular nucleic acid-binding protein
• Protein Accession #: NP_003409
• Purification: Affinity Purified
• Nucleotide Accession #: NM_003418
• Tested Species Reactivity: Human
• Gene Symbol: CNBP
• Predicted Species Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Rabbit
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
• Image 1: Human brain
  
  WB Suggested Anti-CNBP Antibody Titration: 0.2-1 ug/ml
  ELISA Titer: 1:2500
  Positive Control: Human brain
• Image 2:
  
  25 ug of the indicated Human whole cell extracts was loaded onto a 10-20% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment.