Product Number |
ARP34777_T100 |
Product Page |
www.avivasysbio.com/crem-antibody-n-terminal-region-arp34777-t100.html |
Name |
CREM Antibody - N-terminal region (ARP34777_T100) |
Protein Size (# AA) |
120 amino acids |
Molecular Weight |
13kDa |
NCBI Gene Id |
1390 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
CAMP responsive element modulator |
Alias Symbols |
ICER, CREM-2, hCREM-2 |
Peptide Sequence |
Synthetic peptide located within the following region: MAAATGDMPTYQIRAPTAALPQGVVMAASPGSLHSPQQLAEEATRKRELR |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Kimura,K., et al., (2006) Genome Res. 16 (1), 55-65 |
Description of Target |
CREM is a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. |
Protein Interactions |
CREB1; PIAS3; CASP8AP2; UBE2I; UBC; SP100; ATXN1; EMP3; HHV8GK18_gp81; MAPK3; CREB3L4; HDAC1; CREB3L1; TAF4; CAMK2D; GSK3A; FHL5; GSK3B; KCNIP3; CAMK2G; PRKACA; CSNK1A1; CREBBP; TBP; PRKCA; SPI1; CREM; ATF1; CDC34; CDK1; CSNK2A2; CSNK2A1; CD34; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-CREM (ARP34777_T100) antibody |
Blocking Peptide |
For anti-CREM (ARP34777_T100) antibody is Catalog # AAP34777 (Previous Catalog # AAPP05971) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human CREM |
Uniprot ID |
O75519 |
Protein Name |
cAMP-responsive element modulator |
Publications |
Sunahori, K., Juang, Y.-T. & Tsokos, G. C. Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity. J. Immunol. 182, 1500-8 (2009). 19155497 |
Protein Accession # |
NP_874386 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_182717 |
Tested Species Reactivity |
Human |
Gene Symbol |
CREM |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 79% |
Image 1 | Human Jurkat
| WB Suggested Anti-CREM Antibody Titration: 2.5ug/ml ELISA Titer: 1:1562500 Positive Control: Jurkat cell lysate |
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