CREM Antibody - N-terminal region (ARP34777_T100)

Data Sheet
 
Product Number ARP34777_T100
Product Page www.avivasysbio.com/crem-antibody-n-terminal-region-arp34777-t100.html
Name CREM Antibody - N-terminal region (ARP34777_T100)
Protein Size (# AA) 120 amino acids
Molecular Weight 13kDa
NCBI Gene Id 1390
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name CAMP responsive element modulator
Alias Symbols ICER, CREM-2, hCREM-2
Peptide Sequence Synthetic peptide located within the following region: MAAATGDMPTYQIRAPTAALPQGVVMAASPGSLHSPQQLAEEATRKRELR
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Kimura,K., et al., (2006) Genome Res. 16 (1), 55-65
Description of Target CREM is a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
Protein Interactions CREB1; PIAS3; CASP8AP2; UBE2I; UBC; SP100; ATXN1; EMP3; HHV8GK18_gp81; MAPK3; CREB3L4; HDAC1; CREB3L1; TAF4; CAMK2D; GSK3A; FHL5; GSK3B; KCNIP3; CAMK2G; PRKACA; CSNK1A1; CREBBP; TBP; PRKCA; SPI1; CREM; ATF1; CDC34; CDK1; CSNK2A2; CSNK2A1; CD34;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-CREM (ARP34777_T100) antibody
Blocking Peptide For anti-CREM (ARP34777_T100) antibody is Catalog # AAP34777 (Previous Catalog # AAPP05971)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human CREM
Uniprot ID O75519
Protein Name cAMP-responsive element modulator
Publications

Sunahori, K., Juang, Y.-T. & Tsokos, G. C. Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity. J. Immunol. 182, 1500-8 (2009). 19155497

Protein Accession # NP_874386
Purification Protein A purified
Nucleotide Accession # NM_182717
Tested Species Reactivity Human
Gene Symbol CREM
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 79%
Image 1
Human Jurkat
WB Suggested Anti-CREM Antibody Titration: 2.5ug/ml
ELISA Titer: 1:1562500
Positive Control: Jurkat cell lysate
 

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