| Product Number |
ARP34387_T100 |
| Product Page |
www.avivasysbio.com/zyx-antibody-middle-region-arp34387-t100.html |
| Name |
ZYX Antibody - middle region (ARP34387_T100) |
| Protein Size (# AA) |
572 amino acids |
| Molecular Weight |
61kDa |
| NCBI Gene Id |
7791 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Zyxin |
| Alias Symbols |
ESP-2, HED-2 |
| Peptide Sequence |
Synthetic peptide located within the following region: GSPQPPSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEV |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Li,B., et al., (2004) J. Biol. Chem. 279 (19), 20401-20410 |
| Description of Target |
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. |
| Protein Interactions |
RTN4IP1; YPEL3; IMP3; PHF21A; PDLIM5; LIN7A; SUMO1; NEDD8; FAM129B; CORO1B; CAND1; PUF60; PAPOLA; NUDC; SEC23B; SEC24C; HIST1H4A; UGP2; TARS; PXN; GART; GARS; APEH; FN1; HIPK3; VCAM1; UBC; UBL7; UFC1; UBXN7; ZC3H7B; TTLL12; FERMT2; TOMM34; AHCYL1; SSSCA1; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-ZYX (ARP34387_T100) antibody |
| Blocking Peptide |
For anti-ZYX (ARP34387_T100) antibody is Catalog # AAP34387 (Previous Catalog # AAPY00229) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human ZYX |
| Uniprot ID |
Q15942 |
| Protein Name |
Zyxin |
| Publications |
Moody, J. D. et al. A zyxin head-tail interaction regulates zyxin-VASP complex formation. Biochem. Biophys. Res. Commun. 378, 625-8 (2009). 19061869 |
| Sample Type Confirmation |
ZYX is strongly supported by BioGPS gene expression data to be expressed in HeLa |
| Protein Accession # |
NP_003452 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_003461 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
ZYX |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 85%; Dog: 92%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 85%; Rabbit: 92%; Rat: 91% |
| Image 1 | Human Jurkat
 | WB Suggested Anti-ZYX Antibody Titration: 1.25ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysate |
|
| Image 2 | Human HeLa
 | Sample Type: HeLa whole cell lysatePrimary Dilution: 1:200ZYX is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells |
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