| Product Number |
ARP34372_P050 |
| Product Page |
www.avivasysbio.com/chd4-antibody-n-terminal-region-arp34372-p050.html |
| Name |
CHD4 Antibody - N-terminal region (ARP34372_P050) |
| Protein Size (# AA) |
1912 amino acids |
| Molecular Weight |
218kDa |
| NCBI Gene Id |
1108 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Chromodomain helicase DNA binding protein 4 |
| Description |
|
| Alias Symbols |
CHD-4, Mi-2b, SIHIWES, Mi2-BETA |
| Peptide Sequence |
Synthetic peptide located within the following region: QKKERMLLCRQLGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKL |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Sillibourne,J.E., (2007) Mol. Biol. Cell 18 (9), 3667-3680 |
| Description of Target |
CHD4 is a probable transcription regulator.The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
SUMO2; SUMO3; DNMT3B; DNMT1; NACC2; UBC; LGR4; RPA3; RPA2; RPA1; EED; RNF2; SUZ12; BMI1; GATAD2A; HDAC2; HDAC1; MTA3; CSNK2A1; HIST3H3; VCAM1; ITGA4; NOTCH1; ESR1; TBL1XR1; MBD3; MTA2; SMARCC1; RBBP7; RBBP4; CHD3; SNAI1; SNAI2; SUMO1; NEDD8; MTA1; NR2C2; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CHD4 (ARP34372_P050) antibody |
| Blocking Peptide |
For anti-CHD4 (ARP34372_P050) antibody is Catalog # AAP34372 (Previous Catalog # AAPY00214) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human CHD4 |
| Uniprot ID |
Q14839 |
| Protein Name |
Chromodomain-helicase-DNA-binding protein 4 |
| Publications |
Mta2 promotes Tipin-dependent maintenance of replication fork integrity. Cell Cycle. 13, 2120-8 (2014). 24830473 |
| Sample Type Confirmation |
There is BioGPS gene expression data showing that CHD4 is expressed in OVCAR3 |
| Protein Accession # |
NP_001264 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_001273 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CHD4 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93% |
| Image 1 | Human OVCAR-3
 | WB Suggested Anti-CHD4 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: OVCAR-3 cell lysateThere is BioGPS gene expression data showing that CHD4 is expressed in OVCAR3 |
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