| Product Number |
ARP33481_P050-HRP |
| Product Page |
www.avivasysbio.com/nr1h2-antibody-middle-region-hrp-arp33481-p050-hrp.html |
| Name |
NR1H2 Antibody - middle region : HRP (ARP33481_P050-HRP) |
| Protein Size (# AA) |
461 amino acids |
| Molecular Weight |
51kDa |
| Conjugation |
HRP: Horseradish Peroxidase |
| NCBI Gene Id |
7376 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Nuclear receptor subfamily 1, group H, member 2 |
| Alias Symbols |
NER, UNR, LXRB, LXR-b, NER-I, RIP15 |
| Peptide Sequence |
Synthetic peptide located within the following region: ETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYAL |
| Product Format |
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6. |
| Reference |
Schmuth,M., (2008) J. Lipid Res. 49 (3), 499-509 |
| Description of Target |
NR1H2 is an orphan receptor. NR1H2 binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4).The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995 [PubMed 7625741]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
RXRG; MDFI; KDM1A; SUV39H1; ACVRL1; LAMC3; NCOR2; YY1; NPY; CDKN1A; PPARGC1B; PDCD4; PIAS1; USP7; PRKCA; SENP3; CORO2A; MPP1; COL4A5; CHD3; RMI1; CSAD; DUSP12; C14orf1; FAF1; SPRY2; HMGXB4; SORBS2; BAG6; VIM; UBE2D1; SMPD1; ROBO2; NCOR1; NRIP1; NCOA3; VDR |
| Reconstitution and Storage |
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Datasheets/Manuals |
Printable datasheet for anti-NR1H2 (ARP33481_P050-HRP) antibody |
| Blocking Peptide |
For anti-NR1H2 (ARP33481_P050-HRP) antibody is Catalog # AAP33481 (Previous Catalog # AAPP04531) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human NR1H2 |
| Uniprot ID |
P55055 |
| Protein Name |
Oxysterols receptor LXR-beta |
| Publications |
Fu, Y. et al. ABCA12 Regulates ABCA1-Dependent Cholesterol Efflux from Macrophages and the Development of Atherosclerosis. Cell Metab. 18, 225-38 (2013). WB, IP, ICC/IF, Rat, Human, Rabbit, Dog, Pig, Horse, Bovine, Guinea pig, Mouse 23931754 |
| Protein Accession # |
NP_009052 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_007121 |
| Gene Symbol |
NR1H2 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% |
| Image 1 | |
