| Product Number |
ARP33481_P050 |
| Product Page |
www.avivasysbio.com/nr1h2-antibody-middle-region-arp33481-p050.html |
| Name |
NR1H2 Antibody - middle region (ARP33481_P050) |
| Protein Size (# AA) |
461 amino acids |
| Molecular Weight |
51kDa |
| NCBI Gene Id |
7376 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Nuclear receptor subfamily 1, group H, member 2 |
| Alias Symbols |
NER, UNR, LXRB, LXR-b, NER-I, RIP15 |
| Peptide Sequence |
Synthetic peptide located within the following region: ETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYAL |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Schmuth,M., (2008) J. Lipid Res. 49 (3), 499-509 |
| Description of Target |
NR1H2 is an orphan receptor. NR1H2 binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4).The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995 [PubMed 7625741]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
RXRG; MDFI; KDM1A; SUV39H1; ACVRL1; LAMC3; NCOR2; YY1; NPY; CDKN1A; PPARGC1B; PDCD4; PIAS1; USP7; PRKCA; SENP3; CORO2A; MPP1; COL4A5; CHD3; RMI1; CSAD; DUSP12; C14orf1; FAF1; SPRY2; HMGXB4; SORBS2; BAG6; VIM; UBE2D1; SMPD1; ROBO2; NCOR1; NRIP1; NCOA3; VDR |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-NR1H2 (ARP33481_P050) antibody |
| Blocking Peptide |
For anti-NR1H2 (ARP33481_P050) antibody is Catalog # AAP33481 (Previous Catalog # AAPP04531) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human NR1H2 |
| Uniprot ID |
P55055 |
| Protein Name |
Oxysterols receptor LXR-beta |
| Publications |
Fu, Y. et al. ABCA12 Regulates ABCA1-Dependent Cholesterol Efflux from Macrophages and the Development of Atherosclerosis. Cell Metab. 18, 225-38 (2013). 23931754 |
| Protein Accession # |
NP_009052 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_007121 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
NR1H2 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% |
| Image 1 | Transfected 293T
 | WB Suggested Anti-NR1H2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: Transfected 293T |
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