| Product Number |
ARP33256_P050 |
| Product Page |
www.avivasysbio.com/tlr9-antibody-n-terminal-region-arp33256-p050.html |
| Name |
TLR9 Antibody - N-terminal region (ARP33256_P050) |
| Protein Size (# AA) |
1032 amino acids |
| Molecular Weight |
113kDa |
| NCBI Gene Id |
54106 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Toll-like receptor 9 |
| Alias Symbols |
CD289 |
| Peptide Sequence |
Synthetic peptide located within the following region: VGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLN |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Kamine,J., (2008) Infect. Immun. 76 (5), 2123-2129 |
| Description of Target |
TLR9 participates in the innate immune response to microbial agents. TLR9 detects the unmethylated cytidine-phosphate-guanosine (CpG) motifs present in bacterial DNA. TLR9 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
SYK; BTK; STK11IP; UNC93B1; UGGT1; TOLLIP; PALD1; TRAF3; CLGN; TRIM69; TBK1; STUB1; TRAF6; SRC; PRKCZ; MYD88; IRAK1; HSPA8; RNF216; SIGIRR; MAPK8IP3; TLR1; HRAS; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-TLR9 (ARP33256_P050) antibody |
| Blocking Peptide |
For anti-TLR9 (ARP33256_P050) antibody is Catalog # AAP33256 (Previous Catalog # AAPP04294) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human TLR9 |
| Uniprot ID |
Q9NR96 |
| Protein Name |
Toll-like receptor 9 |
| Protein Accession # |
NP_059138 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_017442 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
TLR9 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Pig, Rabbit, Sheep |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 85%; Goat: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 86%; Pig: 100%; Rabbit: 86%; Rat: 93%; Sheep: 100% |
| Image 1 | Human ACHN
 | WB Suggested Anti-TLR9 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: ACHN cell lysate |
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