| Product Number |
ARP32763_P050 |
| Product Page |
www.avivasysbio.com/pias3-antibody-middle-region-arp32763-p050.html |
| Name |
PIAS3 Antibody - middle region (ARP32763_P050) |
| Protein Size (# AA) |
628 amino acids |
| Molecular Weight |
68kDa |
| NCBI Gene Id |
10401 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Protein inhibitor of activated STAT, 3 |
| Alias Symbols |
ZMIZ5 |
| Peptide Sequence |
Synthetic peptide located within the following region: DEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQGGDPSENKKK |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Roukens,M.G., (2008) Mol. Cell. Biol. 28 (7), 2342-2357 |
| Description of Target |
PIAS3 is a member of the protein inhibitor of activated STAT (PIAS) family. It also activates TGF-beta/SMAD transcriptional responses. This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
UBC; HIC1; TRIM63; TRIM55; TAB2; SUMO1; CBS; SUMO2; SUMO3; STAT3; NCOA2; CREM; PRPF40A; SERPINA10; GEMIN4; UBE2I; SKIL; HNRNPK; ZFHX3; SERBP1; SATB1; ERBB4; Bcl11a; ELAVL1; PPP1CA; Grm7; Grm8; Grm6; Grm4; TRIM8; RAC1; C19orf60; CARHSP1; UBA1; PSMC1; TRIM2 |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-PIAS3 (ARP32763_P050) antibody |
| Blocking Peptide |
For anti-PIAS3 (ARP32763_P050) antibody is Catalog # AAP32763 (Previous Catalog # AAPP03778) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human PIAS3 |
| Uniprot ID |
Q9Y6X2 |
| Protein Name |
E3 SUMO-protein ligase PIAS3 |
| Protein Accession # |
NP_006090 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_006099 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
PIAS3 |
| Predicted Species Reactivity |
Human, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 79%; Dog: 86%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Rabbit: 79%; Rat: 79% |
| Image 1 | Human Spleen
 | WB Suggested Anti-PIAS3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human Spleen |
|
