| Product Number |
ARP32515_P050 |
| Product Page |
www.avivasysbio.com/suz12-antibody-middle-region-arp32515-p050.html |
| Name |
SUZ12 Antibody - middle region (ARP32515_P050) |
| Protein Size (# AA) |
739 amino acids |
| Molecular Weight |
83kDa |
| NCBI Gene Id |
23512 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Suppressor of zeste 12 homolog (Drosophila) |
| Alias Symbols |
CHET9, IMMAS, JJAZ1 |
| Peptide Sequence |
Synthetic peptide located within the following region: TGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQ |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Li,H., (2007) Proc. Natl. Acad. Sci. U.S.A. 104 (50), 20001-20006 |
| Description of Target |
A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t (7;17)(p15;q21) with JAZF1 generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
FBXW11; EZH2; BRCA1; CDK5RAP2; RBM22; LUC7L; NHP2; H2AFY2; C17orf85; NAT10; ATAD3A; HEATR1; PTCD3; CHCHD3; CDKAL1; DDX56; GDAP1; LUC7L3; SF3B6; LUC7L2; NOP58; LIMA1; CDC40; CRNKL1; HP1BP3; STOML2; TRA2A; RBM15B; REPIN1; PRPF19; AKAP8L; TBL2; DAZAP1; PHGDH |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-SUZ12 (ARP32515_P050) antibody |
| Additional Information |
IHC Information: Paraffin embedded placenta tissue, tested with an antibody dilution of 5 ug/ml. |
| Blocking Peptide |
For anti-SUZ12 (ARP32515_P050) antibody is Catalog # AAP32515 (Previous Catalog # AAPP03518) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human SUZ12 |
| Uniprot ID |
Q15022 |
| Protein Name |
Polycomb protein SUZ12 |
| Sample Type Confirmation |
SUZ12 is strongly supported by BioGPS gene expression data to be expressed in HeLa |
| Protein Accession # |
NP_056170 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_015355 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
SUZ12 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit |
| Application |
CHIP, IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100% |
| Image 1 | Human Placenta
 | Placenta |
|
| Image 2 | Human HeLa
 | WB Suggested Anti-SUZ12 Antibody Titration: 0.2-1 ug/ml
Positive Control: Hela cell lysateSUZ12 is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells |
|
| Image 3 | HCT116
 | Chromatin Immunoprecipitation (ChIP) Using SUZ12 antibody - middle region (ARP32515_P050) and HCT116 Cells |
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