Product Number |
ARP32475_P050 |
Product Page |
www.avivasysbio.com/src-antibody-n-terminal-region-arp32475-p050.html |
Name |
SRC Antibody - N-terminal region (ARP32475_P050) |
Protein Size (# AA) |
536 amino acids |
Molecular Weight |
60kDa |
NCBI Gene Id |
6714 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) |
Alias Symbols |
ASV, SRC1, THC6, c-SRC, p60-Src |
Peptide Sequence |
Synthetic peptide located within the following region: MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGP |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Pechkovsky,D.V., (2008) J. Biol. Chem. 283 (19), 12898-12908 |
Description of Target |
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. SRC protein is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. |
Protein Interactions |
PSMB9; POLR2L; POLR2K; POLR2J; POLR2I; POLR2H; POLR2G; POLR2F; POLR2E; POLR2D; POLR2C; POLR2B; POLR2A; NEDD4; MAPT; ESR1; CA3; ARRB2; UBC; SRC; SPRR2A; IKBKG; CBLC; ZNF658B; TLR4; RGS16; PTGER4; EGFR; ARRB1; TNFRSF1A; KHDRBS1; SYK; CD44; ENO1; ANXA7; PIK3 |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-SRC (ARP32475_P050) antibody |
Blocking Peptide |
For anti-SRC (ARP32475_P050) antibody is Catalog # AAP32475 (Previous Catalog # AAPP03474) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human SRC |
Uniprot ID |
P12931 |
Protein Name |
Proto-oncogene tyrosine-protein kinase Src |
Protein Accession # |
NP_938033 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_198291 |
Tested Species Reactivity |
Human |
Gene Symbol |
SRC |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 85%; Dog: 92%; Guinea Pig: 92%; Human: 100%; Mouse: 100%; Rabbit: 77%; Rat: 100% |
Image 1 | Human 293T
| WB Suggested Anti-SRC Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: 293T cell lysate |
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Image 2 | human ovarian carcinoma
| SRC antibody - N-terminal region (ARP32475_P050) validated by WB using total cell lysate from human ovarian carcinoma cells at 1:1000. |
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