Product Number |
ARP32432_P050 |
Product Page |
www.avivasysbio.com/pitx2-antibody-n-terminal-region-arp32432-p050.html |
Name |
PITX2 Antibody - N-terminal region (ARP32432_P050) |
Protein Size (# AA) |
317 amino acids |
Molecular Weight |
35kDa |
NCBI Gene Id |
5308 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Paired-like homeodomain 2 |
Alias Symbols |
RS, RGS, ARP1, Brx1, IDG2, IGDS, IHG2, PTX2, RIEG, ASGD4, IGDS2, IRID2, Otlx2, RIEG1 |
Peptide Sequence |
Synthetic peptide located within the following region: EFTDSPESRKEAASSKFFPRQHPGANEKDKSQQGKNEDVGAEDPSKKKRQ |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Holmberg,J., (er) BMC Dev. Biol. 8, 25 (2008) |
Description of Target |
The PITX2 gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. Mutations in PITX2 are associated with Axenfeld-Rieger syndrome (ARS), iridogoniodysgenesis syndrome (IGDS), and sporadic cases of Peters anomaly. This protein is involved in the development of the eye, tooth and abdominal organs. It also acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. |
Protein Interactions |
LEF1; Hoxa1; WDR5; SMAD3; HDAC1; CTNNB1; ZNHIT3; TRIM25; HERC5; PDLIM1; PITX2; PROP1; KAT5; Pou1f1; MSX2; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-PITX2 (ARP32432_P050) antibody |
Blocking Peptide |
For anti-PITX2 (ARP32432_P050) antibody is Catalog # AAP32432 (Previous Catalog # AAPP03428) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human PITX2 |
Uniprot ID |
Q99697 |
Protein Name |
Pituitary homeobox 2 |
Protein Accession # |
NP_700475 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_153426 |
Tested Species Reactivity |
Human, Mouse |
Gene Symbol |
PITX2 |
Predicted Species Reactivity |
Human, Mouse, Horse |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Horse: 86%; Human: 100%; Mouse: 93% |
Image 1 | Human Heart
| WB Suggested Anti-PITX2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:31250 Positive Control: Human heart |
| Image 2 | Mouse Brain
| Host: Mouse Target Name: PITX2 Sample Tissue: Mouse Brain Antibody Dilution: 1ug/ml |
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