| Product Number |
ARP32349_P050 |
| Product Page |
www.avivasysbio.com/ruvbl1-antibody-n-terminal-region-arp32349-p050.html |
| Name |
RUVBL1 Antibody - N-terminal region (ARP32349_P050) |
| Protein Size (# AA) |
456 amino acids |
| Molecular Weight |
50kDa |
| NCBI Gene Id |
8607 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
RuvB-like 1 (E. coli) |
| Alias Symbols |
RVB1, TIH1, ECP54, TIP49, ECP-54, INO80H, NMP238, PONTIN, TIP49A, NMP 238, Pontin52 |
| Peptide Sequence |
Synthetic peptide located within the following region: KIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGV |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Jha,S., (2008) Mol. Cell. Biol. 28 (8), 2690-2700 |
| Description of Target |
RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is the component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. |
| Protein Interactions |
RUVBL2; HUWE1; CEP250; RPAP3; UBC; NEDD8; SUMO1; RNF2; EED; rev; NEDD4; CDC42; IQGAP1; PARK2; FBXO6; USP49; FBXO46; FBXW4; RBM8A; TELO2; TTI1; URI1; RUVBL1; TRRAP; TUBA1A; TUBB; SMG9; UPF1; PRKDC; POLR2E; NCBP1; LMNA; HSPA4; SMG8; PIH1D1; PABPC1; SMG1; PA |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-RUVBL1 (ARP32349_P050) antibody |
| Blocking Peptide |
For anti-RUVBL1 (ARP32349_P050) antibody is Catalog # AAP32349 (Previous Catalog # AAPP03338) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human RUVBL1 |
| Uniprot ID |
Q9Y265 |
| Protein Name |
RuvB-like 1 |
| Protein Accession # |
NP_003698 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_003707 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
RUVBL1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Goat: 77%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
| Image 1 | Human Heart
 | WB Suggested Anti-RUVBL1 Antibody Titration: 0.2-1 ug/ml
Positive Control: Human heart |
|
| Image 2 | Human Fetal Lung
 | Host: Rabbit
Target Name: RUVBL1
Sample Type: Human Fetal Lung
Antibody Dilution: 1.0ug/ml |
|
| Image 3 | K562
 | WB Suggested Anti-RUVBL1 Antibody
Positive Control: Lane 1: 30ug K562 lysate
Primary Antibody Dilution : 1:200
Secondary Antibody : Anti-rabbit-HRP
Secondry Antibody Dilution : 1:1000
Submitted by: Sustackova Gabriela |
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