Product Number |
ARP31992_P050 |
Product Page |
www.avivasysbio.com/irf3-antibody-c-terminal-region-arp31992-p050.html |
Name |
IRF3 Antibody - C-terminal region (ARP31992_P050) |
Protein Size (# AA) |
427 amino acids |
Molecular Weight |
47kDa |
NCBI Gene Id |
3661 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Interferon regulatory factor 3 |
Alias Symbols |
IIAE7 |
Peptide Sequence |
Synthetic peptide located within the following region: SWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHP |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Korherr,C., (2006) Proc. Natl. Acad. Sci. U.S.A. 103 (11), 4240-4245 |
Description of Target |
IRF3 is interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. |
Protein Interactions |
IRF3; UBC; TMEM173; POLR2A; DEAF1; CREBBP; MAFB; vIRF-3; SMAD4; SMAD2; FOXO1; vIRF-1; EP300; SGTA; PEX19; HSP90AA1; PIAS4; TBK1; TOMM70A; TLR2; MAPK9; MAPK8; MAVS; DDX58; TRAF3; ISG15; TRIM21; PIN1; IRF7; HERC5; IKBKE; CUL1; SUMO2; XIAP; HDAC3; SOCS1; RBL |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-IRF3 (ARP31992_P050) antibody |
Blocking Peptide |
For anti-IRF3 (ARP31992_P050) antibody is Catalog # AAP31992 (Previous Catalog # AAPP23941) |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human IRF3 |
Uniprot ID |
Q14653 |
Protein Name |
Interferon regulatory factor 3 |
Protein Accession # |
NP_001562 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_001571 |
Tested Species Reactivity |
Human |
Gene Symbol |
IRF3 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 100%; Sheep: 100% |
Image 1 | Human HepG2
| WB Suggested Anti-IRF3 Antibody Titration: 0.2-1 ug/ml Positive Control: HepG2 cell lysate |
|
Image 2 | Human Lymph Node
| Rabbit Anti-IRF3 Antibody Catalog Number: ARP31992_P050 Formalin Fixed Paraffin Embedded Tissue: Human Lymph Node Tissue Observed Staining: Cytoplasm Primary Antibody Concentration: 1:100 Other Working Concentrations: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec |
|
Image 3 | Human PANC1 Whole Cell
| Host: Rabbit Target Name: IRF3 Sample Tissue: Human PANC1 Whole Cell Antibody Dilution: 3ug/ml |
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