IRF3 Antibody - C-terminal region (ARP31992_P050)

Data Sheet
 
Product Number ARP31992_P050
Product Page www.avivasysbio.com/irf3-antibody-c-terminal-region-arp31992-p050.html
Name IRF3 Antibody - C-terminal region (ARP31992_P050)
Protein Size (# AA) 427 amino acids
Molecular Weight 47kDa
NCBI Gene Id 3661
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Interferon regulatory factor 3
Alias Symbols IIAE7
Peptide Sequence Synthetic peptide located within the following region: SWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHP
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Korherr,C., (2006) Proc. Natl. Acad. Sci. U.S.A. 103 (11), 4240-4245
Description of Target IRF3 is interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.
Protein Interactions IRF3; UBC; TMEM173; POLR2A; DEAF1; CREBBP; MAFB; vIRF-3; SMAD4; SMAD2; FOXO1; vIRF-1; EP300; SGTA; PEX19; HSP90AA1; PIAS4; TBK1; TOMM70A; TLR2; MAPK9; MAPK8; MAVS; DDX58; TRAF3; ISG15; TRIM21; PIN1; IRF7; HERC5; IKBKE; CUL1; SUMO2; XIAP; HDAC3; SOCS1; RBL
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-IRF3 (ARP31992_P050) antibody
Blocking Peptide For anti-IRF3 (ARP31992_P050) antibody is Catalog # AAP31992 (Previous Catalog # AAPP23941)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human IRF3
Uniprot ID Q14653
Protein Name Interferon regulatory factor 3
Protein Accession # NP_001562
Purification Affinity Purified
Nucleotide Accession # NM_001571
Tested Species Reactivity Human
Gene Symbol IRF3
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 100%; Sheep: 100%
Image 1
Human HepG2
WB Suggested Anti-IRF3 Antibody Titration: 0.2-1 ug/ml
Positive Control: HepG2 cell lysate
Image 2
Human Lymph Node
Rabbit Anti-IRF3 Antibody
Catalog Number: ARP31992_P050
Formalin Fixed Paraffin Embedded Tissue: Human Lymph Node Tissue
Observed Staining: Cytoplasm
Primary Antibody Concentration: 1:100
Other Working Concentrations: 1:600
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec
Image 3
Human PANC1 Whole Cell
Host: Rabbit
Target Name: IRF3
Sample Tissue: Human PANC1 Whole Cell
Antibody Dilution: 3ug/ml
 

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