Product Number |
ARP31944_P050 |
Product Page |
www.avivasysbio.com/foxa2-antibody-middle-region-arp31944-p050.html |
Name |
FOXA2 Antibody - middle region (ARP31944_P050) |
Protein Size (# AA) |
457 amino acids |
Molecular Weight |
48kDa |
NCBI Gene Id |
3170 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Forkhead box A2 |
Alias Symbols |
HNF3B, TCF3B, HNF-3-beta |
Peptide Sequence |
Synthetic peptide located within the following region: ASQAQLGEAAGPASETPAGTESPHSSASPCQEHKRGGLGELKGTPAAALS |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Yang,G., (2008) Blood 111 (1), 392-401 |
Description of Target |
FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young.This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Two transcript variants encoding the same protein have been identified for this gene. This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Two transcript variants encoding the same protein have been identified for this gene. |
Protein Interactions |
PPARGC1B; GSC; EN2; OTX2; ONECUT1; NCOA1; TLE1; MIP; HOXA5; LHX1; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-FOXA2 (ARP31944_P050) antibody |
Blocking Peptide |
For anti-FOXA2 (ARP31944_P050) antibody is Catalog # AAP31944 (Previous Catalog # AAPP02841) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human FOXA2 |
Uniprot ID |
Q9Y261 |
Protein Name |
Hepatocyte nuclear factor 3-beta |
Publications |
Kallas, A., Pook, M., Trei, A. & Maimets, T. SOX2 Is Regulated Differently from NANOG and OCT4 in Human Embryonic Stem Cells during Early Differentiation Initiated with Sodium Butyrate. Stem Cells Int. 2014, 298163 (2014). 24707296
Menga, A. et al. Insight into mechanism of in vitro insulin secretion increase induced by antipsychotic clozapine: role of FOXA1 and mitochondrial citrate carrier. Eur. Neuropsychopharmacol. 23, 978-87 (2013). 22959654
Richards, T. J. et al. Allele-specific transactivation of matrix metalloproteinase 7 by FOXA2 and correlation with plasma levels in idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 302, L746-54 (2012). 22268124 |
Sample Type Confirmation |
FOXA2 is strongly supported by BioGPS gene expression data to be expressed in 721_B, HepG2 |
Protein Accession # |
NP_068556 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_021784 |
Tested Species Reactivity |
Human |
Gene Symbol |
FOXA2 |
Predicted Species Reactivity |
Human, Mouse, Rat, Dog, Horse, Pig, Rabbit |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Dog: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Pig: 100%; Rabbit: 77%; Rat: 92% |
Image 1 | Human HeLa
| WB Suggested Anti-FOXA2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: Hela cell lysate |
|
Image 2 | Human Lung
| Sample Type: Human lung tissue protein extractsPrimary Dilution: 1:1000Secondary (Anti-Rabbit HRP sc-2004) Dilution: 1:1000 |
|
Image 3 | Human 721_B
| Host: Rabbit Target Name: FOXA2 Sample Type: Human 721_B Antibody Dilution: 1.0ug/mlFOXA2 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells |
|
Image 4 | Human HepG2
| Host: Rabbit Target Name: FOXA2 Sample Type: Human HepG2 Antibody Dilution: 1.0ug/mlFOXA2 is strongly supported by BioGPS gene expression data to be expressed in HepG2 |
|
Image 5 | Human Fetal Brain
| Host: Rabbit Target Name: FOXA2 Sample Type: Human Fetal Brain Antibody Dilution: 1.0ug/ml |
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