| Product Number |
ARP31941_T100 |
| Product Page |
www.avivasysbio.com/nr4a1-antibody-n-terminal-region-arp31941-t100.html |
| Name |
NR4A1 Antibody - N-terminal region (ARP31941_T100) |
| Protein Size (# AA) |
598 amino acids |
| Molecular Weight |
66kDa |
| NCBI Gene Id |
3164 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Nuclear receptor subfamily 4, group A, member 1 |
| Description |
|
| Alias Symbols |
HMR, N10, TR3, NP10, GFRP1, NAK-1, NGFIB, NUR77 |
| Peptide Sequence |
Synthetic peptide located within the following region: GTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMD |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Lu,L., et al., (2004) J. Clin. Endocrinol. Metab. 89 (8), 4113-4118 |
| Description of Target |
NR4A1 encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. |
| Protein Interactions |
KRTAP10-5; KRTAP10-1; LONRF1; PGBD1; BCL2L10; CDKN2D; BCL2A1; BCL2; TUBB4A; VASP; ANKIB1; CUTA; NFKB1; SMAD3; LSS; HADHA; GLUD1; GK; CPT1A; SERPING1; ABCC6; ABCC13; SOCS4; ABCG8; DIABLO; HCVgp1; ABCA5; CHEK2; SUGT1; PRDX4; PRDX6; CHD1L; ABCB11; ARHGEF5; U |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-NR4A1 (ARP31941_T100) antibody |
| Blocking Peptide |
For anti-NR4A1 (ARP31941_T100) antibody is Catalog # AAP31941 |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human NR4A1 |
| Uniprot ID |
P22736 |
| Protein Name |
Nuclear receptor subfamily 4 group A member 1 |
| Publications |
Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation. Mol Cell. 69, 480-492.e7 (2018). 29395065
Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation. Nat Commun. 8, 14420 (2017). 28240261 |
| Protein Accession # |
NP_775180 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_173157 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
NR4A1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 92%; Rabbit: 93%; Rat: 93% |
| Image 1 | Human Testis
 | Human Testis |
|
| Image 2 | Human Stomach
 | Rabbit Anti-NR4A1 Antibody
Catalog Number: ARP31941
Paraffin Embedded Tissue: Human Stomach
Cellular Data: Mucous Cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X |
|
| Image 3 | Human Liver
 | Rabbit Anti-NR4A1 Antibody
Catalog Number: ARP31941
Paraffin Embedded Tissue: Human Liver
Cellular Data: Hepatocytes
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X |
|
| Image 4 | Human 786-0 Whole Cell
 | Host: Rabbit
Target Name: NR4A1
Sample Tissue: Human 786-0 Whole Cell
Antibody Dilution: 1ug/ml |
|
| Image 5 | Human lung, Human brain
 | Host: Rabbit
Target: NR4A1
Positive control (+): Human lung (LU)
Negative control (-): Human brain (BR)
Antibody concentration: 1ug/ml |
|
| Image 6 | Human Hela
 | Host: Rabbit
Target Name: NR4A1
Sample Tissue: Human Hela
Antibody Dilution: 1.0ug/ml |
|
