CSEN Antibody - N-terminal region (ARP31932_P050)

Data Sheet
 
Product Number ARP31932_P050
Product Page www.avivasysbio.com/csen-antibody-n-terminal-region-arp31932-p050.html
Name CSEN Antibody - N-terminal region (ARP31932_P050)
Protein Size (# AA) 256 amino acids
Molecular Weight 29kDa
NCBI Gene Id 30818
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Kv channel interacting protein 3, calsenilin
Alias Symbols CSEN, DREAM, KCHIP3
Peptide Sequence Synthetic peptide located within the following region: STVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYA
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Zaidi,N.F., et al., (2004) J. Neurochem. 89 (3), 593-601
Description of Target CSEN is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The protein encoded by this gene is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease.
Protein Interactions MAVS; CD177; IGLV3-25; IL6ST; IGF1R; KCND2; CLN3; CALM2; KCNIP3; PPP3CA; GRK6; ADRBK1; UBE2I; UBC; PCBD2; TARBP2; PSEN2; CASP3; CREM; CREB1; PSEN1; CRK;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-KCNIP3 (ARP31932_P050) antibody
Blocking Peptide For anti-KCNIP3 (ARP31932_P050) antibody is Catalog # AAP31932 (Previous Catalog # AAPP02829)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human CSEN
Uniprot ID Q9Y2W7
Protein Name Calsenilin
Publications

Fernandes, V. S. et al. Endogenous hydrogen sulfide has a powerful role in inhibitory neurotransmission to the pig bladder neck. J. Urol. 189, 1567-73 (2013). 23063804

Protein Accession # NP_038462
Purification Affinity Purified
Nucleotide Accession # NM_013434
Tested Species Reactivity Human, Mouse
Gene Symbol KCNIP3
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92%
Image 1
Human Jurkat
WB Suggested Anti-CSEN Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysate
Image 2
Human kidney
Human kidney
Image 3
Mouse Brain
Host: Mouse
Target Name: KCNIP3
Sample Tissue: Mouse Brain
Antibody Dilution: 1ug/ml
 

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