COPS5 Antibody - N-terminal region (ARP31512_P050)

• Product Number: ARP31512_P050
• Name: COPS5 Antibody - N-terminal region (ARP31512_P050)
• Protein Size (# AA): 334 amino acids
• Molecular Weight: 37kDa
• Subunit: 5
• NCBI Gene Id: 10987
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
• Alias Symbols: CSN5, JAB1, SGN5, MOV-34
• Peptide Sequence: Synthetic peptide located within the following region: AASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHY
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Zhang,X.C., (2008) J. Cell. Biochem. 103 (4), 1219-1230
• Description of Target: COPS5 is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Protein Interactions: COPS6; UBC; CUL1; NEDD8; PTGS2; GPS1; LRP1; RANBP9; APP; SIAH1; BACE1; CTNNB1; COPS5; STAT3; CREB3; COPS4; SART3; COPS3; EPB41L1; CAST; KIF5B; PDLIM7; SMAD4; FBXO6; COPS2; TYK2; CDK2; CENPW; CENPT; FBXW4; MYEOV2; COPS8; CHUK; IKBKB; DTL; CD93; DDO; SMAD2;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-COPS5 (ARP31512_P050) antibody is Catalog # AAP31512 (Previous Catalog # AAPP02274)
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human COPS5
• Uniprot ID: Q92905
• Protein Name: COP9 signalosome complex subunit 5
• Protein Accession #: NP_006828
• Purification: Affinity Purified
• Nucleotide Accession #: NM_006837
• Tested Species Reactivity: Human
• Gene Symbol: COPS5
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
• Image 1: Mouse B8, Human HEK293
  
  Sample Type: 1. Human blood cells, pure
  2. Human blood cells, partially purified
  3. and 4. Human total cell extract, extraction only
  Primary Dilution: 1:500
  Secondary Anitbody: HRP conjugated anti-rabbit
  Image Submitted By: Dr. Elah Pick
  University of Haifa at Oranim 
• Image 2: Human Muscle
  
  WB Suggested Anti-COPS5 Antibody Titration: 0.2-1 ug/ml
  ELISA Titer: 1:2500
  Positive Control: Human Muscle