| Product Number |
ARP31048_P050 |
| Product Page |
www.avivasysbio.com/stat6-antibody-c-terminal-region-arp31048-p050.html |
| Name |
STAT6 Antibody - C-terminal region (ARP31048_P050) |
| Protein Size (# AA) |
847 amino acids |
| Molecular Weight |
94kDa |
| NCBI Gene Id |
6778 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Signal transducer and activator of transcription 6, interleukin-4 induced |
| Alias Symbols |
STAT6B, STAT6C, D12S1644, IL-4-STAT |
| Peptide Sequence |
Synthetic peptide located within the following region: NLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQM |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Li,B.H., (2008) Biochem. Biophys. Res. Commun. 369 (2), 554-560 |
| Description of Target |
Full-length human STAR6 (NP_003144) was expressed in E.coli as inclusion body and purified after protein refolding for mouse immunization. Clone 5B1 shows excellent western blot detection of endogenous STAT6 using ACHN cell lysate.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
UBC; IRF4; PDE12; EHD1; USP8; API5; PGGT1B; EP300; TRIM28; JAK3; RCN3; LITAF; IL4R; EEF1A1; VKORC1; PTPN2; STAT2; JAK1; IFNG; IFNAR1; SRXN1; PSAT1; DSTN; SEC24A; AHCYL1; SSSCA1; NUBP2; SH3BGRL; RAD23B; PPM1G; IGBP1; CEBPE; SND1; SUMO2; FCER2; SFPQ; IGHE; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-STAT6 (ARP31048_P050) antibody |
| Additional Information |
IHC Information: Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
IHC Information: Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
IHC Information: Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
IHC Information: Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) |
| Blocking Peptide |
For anti-STAT6 (ARP31048_P050) antibody is Catalog # AAP31048 (Previous Catalog # AAPP24027) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human STAT6 |
| Uniprot ID |
P42226 |
| Protein Name |
Signal transducer and activator of transcription 6 |
| Sample Type Confirmation |
STAT6 is strongly supported by BioGPS gene expression data to be expressed in HeLa |
| Protein Accession # |
NP_003144 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_003153 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
STAT6 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
WB, IHC |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% |
| Image 1 | Human Tonsil
 | Human Tonsil |
|
| Image 2 | Human Testis
 | Human Testis |
|
| Image 3 | Human Prostate
 | Human Prostate |
|
| Image 4 | Human Kidney
 | Human Kidney |
|
| Image 5 | Human Lung Tissue
 | STAT6 antibody - C-terminal region (ARP31048_P050)
Catalog Number: ARP31048_P050
Formalin Fixed Paraffin Embedded Tissue: Human Lung Tissue
Observed Staining: Cytoplasm of pneumocytes
Primary Antibody Concentration: 1:600
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec |
|
| Image 6 | Human HeLa
 | WB Suggested Anti-STAT6 Antibody Titration: 1 ug/ml
Positive Control: Hela cell lysateSTAT6 is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells |
|
