| Product Number |
ARP30878_P050 |
| Product Page |
www.avivasysbio.com/ret-antibody-c-terminal-region-arp30878-p050.html |
| Name |
RET Antibody - C-terminal region (ARP30878_P050) |
| Protein Size (# AA) |
1114 amino acids |
| Molecular Weight |
123kDa |
| NCBI Gene Id |
5979 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Ret proto-oncogene |
| Alias Symbols |
PTC, MTC1, HSCR1, MEN2A, MEN2B, CDHF12, CDHR16, RET-ELE1 |
| Peptide Sequence |
Synthetic peptide located within the following region: EMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVK |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. |
| Protein Interactions |
NOTCH2NL; UBC; CBLC; PDLIM7; HSP90AA1; GRB2; CBL; RET; MCRS1; IKBKG; DOK3; DOK5; DOK4; DOK6; SHC3; FRS2; DOK2; AKAP5; CBLB; GAB1; DOK1; NRTN; MAPK3; GRB10; GRB7; GFRA1; MAPK8; GDNF; PTK2; SHC1; MAPK14; SRC; MAPK1; PRKAR2A; PTPN11; PLCG1; PIK3R1; CRK; STAT |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-RET (ARP30878_P050) antibody |
| Blocking Peptide |
For anti-RET (ARP30878_P050) antibody is Catalog # AAP30878 |
| Uniprot ID |
P07949 |
| Protein Name |
Proto-oncogene tyrosine-protein kinase receptor Ret |
| Protein Accession # |
NP_000314 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_000323 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
RET |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 90%; Horse: 100%; Human: 100%; Mouse: 90%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
| Image 1 | Human 293T
 | WB Suggested Anti-RET Antibody
Titration: 1.0 ug/ml
Positive Control: 293T Whole Cell |
|
| Image 2 | Human 293T Whole Cell
 | Host: Rabbit
Target Name: RET
Sample Tissue: Human 293T Whole Cell
Antibody Dilution: 1ug/ml |
|
| Image 3 | Human Testis
 | Rabbit Anti-RET Antibody
Catalog Number: ARP30878_P050
Formalin Fixed Paraffin Embedded Tissue: Human Testis Tissue
Observed Staining: Cytoplasm
Primary Antibody Concentration: 1:600
Other Working Concentrations: N/A
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec |
|
