| Product Number |
ARP30627_P050 |
| Product Page |
www.avivasysbio.com/fas-antibody-middle-region-arp30627-p050.html |
| Name |
FAS Antibody - middle region (ARP30627_P050) |
| Protein Size (# AA) |
335 amino acids |
| Molecular Weight |
36kDa |
| NCBI Gene Id |
355 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Fas (TNF receptor superfamily, member 6) |
| Alias Symbols |
APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6 |
| Peptide Sequence |
Synthetic peptide located within the following region: KKEAYDTLIKDLKKANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. |
| Protein Interactions |
FADD; CAV1; FAS; APOA5; TMX1; UBQLN1; MBD4; TP63; TCAP; BAG6; UBC; HNRNPC; GADD45A; CCND3; ATP6V0B; SQSTM1; Ube2i; PRAM1; RARA; PML; DAXX; FASLG; TRADD; MAP3K5; BMX; Traf1; FAF1; FAF2; TRAF3; KRIT1; TNF; BRE; LRIF1; FEM1B; FBF1; FAIM2; CASP8AP2; C14orf1; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-FAS (ARP30627_P050) antibody |
| Blocking Peptide |
For anti-FAS (ARP30627_P050) antibody is Catalog # AAP30627 (Previous Catalog # AAPP01280) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human FAS |
| Uniprot ID |
P25445 |
| Protein Name |
Tumor necrosis factor receptor superfamily member 6 |
| Protein Accession # |
NP_000034 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_000043 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
FAS |
| Predicted Species Reactivity |
Human, Pig |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Human: 100%; Pig: 80% |
| Image 1 | Human Liver
 | WB Suggested Anti-FAS Antibody Titration: 0.2-1 ug/ml
Positive Control: Human Liver |
|
|
