| Product Number |
ARP30475_T100 |
| Product Page |
www.avivasysbio.com/bcl2l1-antibody-n-terminal-region-arp30475-t100.html |
| Name |
BCL2L1 Antibody - N-terminal region (ARP30475_T100) |
| Protein Size (# AA) |
233 amino acids |
| Molecular Weight |
26kDa |
| NCBI Gene Id |
598 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
BCL2-like 1 |
| Alias Symbols |
BCLX, BCL2L, Bcl-X, PPP1R52, BCL-XL/S |
| Peptide Sequence |
Synthetic peptide located within the following region: SNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAING |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Allikmets,R., (2006) J. Mol. Biol. 356 (2), 367-381 |
| Description of Target |
BCL2L1 encodes a protein which belongs to the BCL-2 protein family. The proteins encoded by BCL2L1 are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis.The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. |
| Protein Interactions |
BCL2L1; BCL2; BAX; BAD; BMF; BBC3; CASP8AP2; BECN1; UBC; TPT1; TP53BP2; ced-9; ced-4; PGAM5; CDKN2A; CASP1; BCL2L11; HRK; PMAIP1; BIK; BID; PARK2; PINK1; BAK1; RAD9A; AKT1; Mapk1; ATXN3; CLU; BCAP31; CRYAB; CRYAA; BFAR; PPP1CC; PPP1CA; ACTB; UBR1; METTL23 |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-BCL2L1 (ARP30475_T100) antibody |
| Blocking Peptide |
For anti-BCL2L1 (ARP30475_T100) antibody is Catalog # AAP30475 (Previous Catalog # AAPP24055) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human BCL2L1 |
| Uniprot ID |
Q07817 |
| Protein Name |
Bcl-2-like protein 1 |
| Sample Type Confirmation |
BCL2L1 is strongly supported by BioGPS gene expression data to be expressed in HepG2 |
| Protein Accession # |
NP_612815 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_138578 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
BCL2L1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 92%; Pig: 100%; Rabbit: 100%; Rat: 93%; Sheep: 100% |
| Image 1 | Human HepG2
 | WB Suggested Anti-BCL2L1 Antibody Titration: 2.5ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysateBCL2L1 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells |
|
